Omega 3 fatty acids lessen severity of osteoarthritis in mice

Mice consuming a supplement of omega 3 fatty acids had healthier joints than those fed diets high in saturated fats and omega 6 fatty acids, according to Duke Medicine researchers.

The findings, published in the Annals of the Rheumatic Diseases, suggest that unhealthy dietary fats – not just obesity – may contribute to worsening osteoarthritis.

“Our results suggest that dietary factors play a more significant role than mechanical factors in the link between obesity and osteoarthritis,” said Farshid Guilak, Ph.D., Laszlo Ormandy Professor of Orthopaedic Surgery at Duke and the study’s senior author.

Obesity is one of the primary risk factors for osteoarthritis, although the mechanisms linking these conditions are not fully understood. It has been assumed that increased weight wears the joints out, but this doesn’t explain why arthritis is also found in hands and other joints that don’t bear weight.

Guilak and his colleagues began studying systemic factors other than body weight to determine their effect on arthritis, and in an earlier study in obese mice, found that the lack of appetite hormone leptin predicted whether the mice had arthritis.

“This made us think that maybe it’s not how much weight you gain, but what you eat,” Guilak said.

In this study, the researchers focused on mice with osteoarthritis of the knee caused by injury to the joint. Arthritis resulting from trauma or injury is thought to account for 10 to 15 percent of all cases of arthritis.

The mice were fed one of three high-fat diets: one rich in saturated fat, one rich in omega 6 fatty acids, and one rich in omega 6 fatty acids but supplemented with a small amount of omega 3 fatty acids.

Saturated fat, which usually comes from animal sources, is known to raise cholesterol levels. Omega 6 fatty acids, often found in corn oil, soybean oil, nuts and seeds, are thought to be a healthier source of fat.

Omega 3 fatty acids, commonly found in fish or fish oil supplements, are often touted as “healthy fat” given their heart-healthy and anti-inflammatory properties. Unfortunately, most Americans eat significantly more saturated fat and omega 6 fatty acids than omega 3 fatty acids.

“A healthy diet would include roughly equal ratios of these fats, but we’re way off the scale in the Western diet,” Guilak said.

The researchers found that arthritis was significantly associated with the mice’s diets, but not with body weight. The mice that ate diets high in saturated fat or omega 6 fatty acids experienced significant worsening of their arthritis, while mice consuming a small supplement of omega 3 fatty acids had healthier joints.

“While omega 3 fatty acids aren’t reversing the injury, they appear to slow the progression of arthritis in this group of mice,” Guilak said. “In fact, omega 3 fatty acids eliminated the detrimental effects of obesity in obese mice.”

The researchers also

… Continue reading here.
Diet And Weight Loss News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com) <p>

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    • Amy Poehler's Smart Girls
    • July 13, 2014

    We just featured an amazing kayaker named Kelly Allen! We’ve completely
    fallen in love with the sport!

    • mati stern
    • July 13, 2014

    olymic kayak is the best ( =

    • pen mightygun
    • July 13, 2014

    im sorry to hear that, about your wife, just like a paddle wifes can be

    • lendoggtheking
    • July 13, 2014

    fitness, in those tanks. I’ll take a k1 any day

    • CuriousCraig2
    • July 13, 2014

    If only people saw more alternatives forms of fitness like kayaking. It
    doesn’t always have to be something you hate.

    • Per Franck
    • July 13, 2014

    hah! i have the same problem. keep up the work on her though, bribes are

    • Donald Couture
    • July 13, 2014

    thanks for sharing this knowledge. i have been bicycling to work for about
    2 years now, something was missing. i just bought a kayak today after
    studying what i need . i am excited to get started and reap the benefit of
    this activity .

    • josephpalauz
    • July 13, 2014

    it so good for the mind too

    • Paul Lockwood
    • July 13, 2014

    im learning

    • adventurecraig
    • July 13, 2014

    Nice little promo vid on kayaking! I ride a narrow canoe, called an
    ‘assegai’ (Zulu spear), on Emmarentia Dam in Johannesburg, South Africa. I
    swam the entire boundary of the dam while learning to balance the boat two
    years ago. Only now am I starting to work properly on my rotation and arm

    • Kyle Davidson
    • July 13, 2014

    come kayak in South Africa! we have the best rivers, best water, best
    clubs, best races and best people! always an adventure! This is a video I
    made of our last weekend out: youtube.com/watch?v=XBEV4XcfoLU

    • Kayak NewsUSA
    • July 13, 2014


    • Shafiul Ahossain
    • July 13, 2014


    • jo3tag
    • July 13, 2014

    Either you get it, or you don’t. After my first paddle, I was hooked. After
    my first rapid, I was hopelessly hooked. I now own five ‘yaks, and take
    anyone I can convince to go. Usually, they have a blast, but there are a
    few that just don’t get that thrill,peaceful sense of mind. Sadly, my wife
    is one

    • Andy Garag
    • July 13, 2014

    this can easily be avoided by using an electric motor

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