Research findings presented today at the European League Against Rheumatism Annual Congress (EULAR 2014) suggest that exercise transiently suppresses local and systemic inflammation, reinforcing the beneficial effects of exercise and the need for this to be regular in order to achieve clinical efficacy in rheumatic disease.
Chronic inflammation, swelling and pain in the joints characterise the more than 200 rheumatic diseases. Persistent inflammation over time can damage affected joints, but previous research has established that exercise can decrease joint inflammation in rheumatoid arthritis.
These new research findings focused on the physiological changes created by exercise and their impact on inflammation. The researchers have found that exercise generates a true biological response and induces changes on a molecular level that stimulate anti-inflammatory effects.
“As the inflammatory process in rheumatic diseases is a major cause of disability, we are excited to uncover the process by which exercise works on a molecular level to decrease this inflammation. Our results show the benefits that exercise could have in decreasing the great burden of rheumatic diseases. They also highlight the need for frequent exercise in order to create clinically significant results,” said Dr. Nicholas Young, presenting author from The Ohio State University Wexner Medical Center, Columbus, Ohio, US.
This in-vivo study measured the regulation and activation of NF-kB* in mice. NF-kB, a protein complex that controls many genes involved in inflammation, is found to be chronically active in many inflammatory diseases, such as inflammatory bowel disease and arthritis.
An inflammatory response was created in mice both before and after exercise through an injection of lipopolysaccharides† (LPS). The impact of exercise was measured over time following the inflammatory response.
There was a strong systemic and local inflammatory response upon injection of LPS, which was strongest at 2 hours post-injection. NF-kB activation was seen as a result of the LPS and was detected in lymphatic tissues throughout the mouse. In those groups where mice were exercised pre- and post-LPS injection, the NF-kB activation was significantly inhibited in whole-body systemic analysis.
The effect of exercise on the inhibition of NF-kB activation was identified as a transient effect, lasting only 24 hours after exercise.
The role of exercise in inhibiting NF-kB activation was linked to the suppression of multiple pro-inflammatory cytokines. Cytokines are produced by a wide range of cells including macrophages and are involved in cell signalling.
Rheumatic disease is a term used to describe over 200 conditions characterised by inflammation, swelling and pain in the joints or muscles. They are leading causes of morbidity and disability, giving rise to enormous healthcare expenditures and loss of work.
The above story is based on materials provided by
… Continue reading here.
Fitness News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com) <p>
some of the best exercises you can do for your core and abs and strengthen your lower back and obliques. it’s a great routine and helps your fitness levels s…
You Can Help Your Child Get More Exercise By Following These 5 Tips
Does your child get enough exercise? You can get your children more active with these 5 fun parenting tips.
Better Health in Four Steps
In just four steps, you can improve your health for the better and this article will show you how. The steps below are bite-sized nuggets of health information you can actually use to live a healthy life. Here we go… Nutritional supplements are the first step As far as I’m concerned, they are very important […]
Top 4 Nutrition Predictions in the New Year
Several food and nutrition trends were in the spotlight this year, including the continued rise of plant-based diets, non-dairy ice creams and superfoods that are blasts from the past — legumes, apples and cabbage. It can be easy to experience nutrition whiplash in the New Year, but don’t be a victim. Get a jump-start on […]
Want to lose weight? Research proves a big breakfast is the first step
If you want to lose weight, you’re not alone. More than half of Americans desire to shed pounds, according to Gallup. This goal inspires people to take action in many ways, from increasing exercise to modifying meals. One thing many people do is skip breakfast in order to lower calorie intake. While this may seem […]
This was not a core training video. More like ab training. No exercises for
the glutes, or low back in this.
I think yoy should do more work out vids
if u know anything about athletics then u wud know this vid is pretty good.
to all y’all dissing him, why don’t u make a better vid and post it up?
Imma get into this
This was in New York
Love how he applies calisthenics. And plyometrics in his other vids.
i love this workout
sorry any one can tell me the name of song? cheers
wow I will be like this