rp_300.JPG

Gene loss creates eating disorder-related behaviors in mice

Building on their discovery of a gene linked to eating disorders in humans, a team of researchers at the University of Iowa has now shown that loss of the gene in mice leads to several behavioral abnormalities that resemble behaviors seen in people with anorexia nervosa.

The team, led by Michael Lutter, MD, PhD, assistant professor of psychiatry in the UI Carver College of Medicine, found that mice that lack the estrogen-related receptor alpha (ESRRA) gene are less motivated to seek out high-fat food when they are hungry and have abnormal social interactions. The effect was stronger in female mice, which also showed increased obsessive-compulsive-like behaviors.

The study also shows that ESRRA levels are controlled by energy status in the mice. Restricting calorie intake to 60 percent of normal over several days significantly increased levels of ESRRA in the brains of normal mice.

“Decreased calorie intake usually motivates animals, including humans, to seek out high-calorie food. These findings suggest that loss of ESRRA activity may disrupt that response,” Lutter says.

Anorexia nervosa and bulimia nervosa are common and severe mental illnesses. Lutter notes that although 50 to 70 percent of the risk of getting an eating disorder is inherited, identifying the genes that mediate this risk has proven difficult.

ESRRA is a transcription factor — a gene that turns on other genes. Lutter and his colleagues previously found that a mutation that reduces ESRRA activity is associated with an increased risk for eating disorders in human patients. Although ESRRA is expressed in many brain regions that are disrupted in anorexia, almost nothing was known about its function in the brain. In the new study, published online April 9 in the journal Cell Reports, Lutter’s team manipulated ESRRA in mice to investigate the gene’s role in behavior.

“This work identifies estrogen-related receptor alpha as one of the genes that is likely to contribute to the risk of getting anorexia nervosa or bulimia nervosa,” Lutter says. “Clearly social factors, particularly the western ideal of thinness, contribute the remaining ‘non-genetic’ risk, and the increasing rate of eating disorders over the past several decades is likely due to social factors, not genetics,” he adds.

Through a series of experiments with genetically engineered mice, Lutter and his team showed that mice without the ESRRA gene have behavioral abnormalities related to eating and social behavior. In particular, mice without ESRRA show reduced effort to work for high-fat food when they are hungry. The mice also exhibited impaired social interaction and female mice without the gene show increased compulsive grooming, which may mimic obsessive-compulsive-type behavior in humans.

In order to refine their understanding of the effects of ESRRA in the brain, the researchers selectively removed the gene from particular brain regions that have been associated with eating disorders. They found that removing the gene from the orbitofrontal cortex was associated with increased obsessive-compulsive-type behaviors in female mice,

… Continue reading here.
Diet And Weight Loss News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com)

Meep Meep Open Me♥ I usually have a yoga mat, but I left it at home. Not even gonna lie, the floor hurt T^T If you like Oolong Tea then I think this would perfect for you since it has…
Video Rating: 4 / 5

Stamina 50 lb. Versa-Bell II Adjustable Dumbbell Model 05-2150, 1 ea


PLEASE NOTE: drugstore.com does not currently ship this product to Missouri residents. Orders for this product with a ship-to address located in Missouri will not be processed and customers will be contacted by drugstore.com Customer Care regarding cancellation. The Stamina Versa-Bell II 50 lb. dumbbell in a pair is nine dumbbells in one. This innovative 10 to 50 pound adjustable dumbbell replaces nine individual dumbbells, but is the size of one so you save space and money without sacrificing quality. It s the perfect way to add dumbbells to your home workout area. Just set the dial to your weight of choice. The dial mechanism makes changing weight fast and easy for uninterrupted workouts. As you dial, the weight minder shows the weight you ve chosen.

Price: $
Sold by drugstore.com

Empower Fitness MP-2975R 4lb Soft Walking Weights


Walk your way to fitness with the Empower Soft Walking Weights. Walking is the #1 activity for women in the U.S. due to its many resulting health benefits. Walking with weights will improve the effectiveness of your workout by increasing calorie burn and toning your upper body.Burn more calories while toning and tightening your upper bodyComfort-fit strap holds weight in place while walking without needing a tight gripDurable, hand washable, neoprene fabric is soft and comfortable on the skinIncludes 4lb combined weight per pairPerfect for multiple activities: walking, light strength training and rehabilitation exercise
List Price: $ 15.80
Price: $ 15.80
[wpramazon asin=”B00BIBCDVE”]

名刺200個のクラシックスポーツ&フィットネスパターン2は,美術撮影紙のカラフルな印刷を両面


スタイル&テーマ:ハイクラス,現代風; 材質:ラミネート紙; 方向:横長; ロゴ/写真フィールド:Without Logo; 防水:はい; 最小注文数量:1; 梱包:ギフトボックス; サイズ(cm):95.4; 正味重量(kg):0.2; セット内容:200pcs; 対応機種:Sports & Fitness
List Price: 3392.0
Price:


You May Also Like These Topics...

5 Ways to Feel Good While Getting Fit

Setting intentions is a powerful thing. Then when you have that shiny new gym membership in hand, you feel like nothing stands between you and your goals to get in shape once and for all. Trouble is, lack of motivation, unpreparedness and busy schedules have a way of interfering with our plans. If you find […]

Error 403 (Forbidden)!!1 body{background:url(//www.google.com/images/errors/robot.png) 100% 5px no-repeat;padding-right:205px}p{margin:11px 0 22px;overflow:hidden}ins{color:#777;text-decoration:none}a img{border:0}@media screen and (max-width:772px){body{background:none;margin-top:0;max-width:none;padding-right:0}}#logo{background:url(//www.google.com/images/branding/googlelogo/1x/googlelogo_color_150x54dp.png) no-repeat;margin-left:-5px}@media only screen and (min-resolution:192dpi){#logo{background:url(//www.google.com/images/branding/googlelogo/2x/googlelogo_color_150x54dp.png) no-repeat 0% 0%/100% 100%;-moz-border-image:url(//www.google.com/images/branding/googlelogo/2x/googlelogo_color_150x54dp.png) 0}}@media only screen and (-webkit-min-device-pixel-ratio:2){#logo{background:url(//www.google.com/images/branding/googlelogo/2x/googlelogo_color_150x54dp.png) no-repeat;-webkit-background-size:100% 100%}}#logo{display:inline-block;height:54px;width:150px}]]>403. That’s an error.Your client does not have permission to get URL / from this server. (Client IP address: 97.74.24.212)That’s all we know.

Error 403 (Forbidden)!!1 body{background:url(//www.google.com/images/errors/robot.png) 100% 5px no-repeat;padding-right:205px}p{margin:11px 0 22px;overflow:hidden}ins{color:#777;text-decoration:none}a img{border:0}@media screen and (max-width:772px){body{background:none;margin-top:0;max-width:none;padding-right:0}}#logo{background:url(//www.google.com/images/branding/googlelogo/1x/googlelogo_color_150x54dp.png) no-repeat;margin-left:-5px}@media only screen and (min-resolution:192dpi){#logo{background:url(//www.google.com/images/branding/googlelogo/2x/googlelogo_color_150x54dp.png) no-repeat 0% 0%/100% 100%;-moz-border-image:url(//www.google.com/images/branding/googlelogo/2x/googlelogo_color_150x54dp.png) 0}}@media only screen and (-webkit-min-device-pixel-ratio:2){#logo{background:url(//www.google.com/images/branding/googlelogo/2x/googlelogo_color_150x54dp.png) no-repeat;-webkit-background-size:100% 100%}}#logo{display:inline-block;height:54px;width:150px}]]>403. That’s an error.Your client does not have permission to get URL / from this server. (Client IP address: 97.74.24.212)That’s all we know.

Fitbit Wireless Activity Cargo HR Wristband, Black, Small

See if you agree with the following statement. Fat loss and weight loss are essentially the same thing, interchangeable. If, like many people, said yes, you guessed wrong. Fat loss and weight loss are not the same thing at all. In fact, they are not even close. If you browse the diet book section of […]

The new rules of weight loss: the new formula weight loss brand that eliminates confusion … reveals how to take steps to lose weight and stay slim … Quick results … look and feel best possible.

The key for fast and permanent fat loss is smarter not harder Working Today the public is confused more than ever about what is the best fat loss program is. Most people are very frustrated and confused about the most effective way to go about the best performing fat loss to get the body they […]

Tags: , , , , , ,
Previous Post

Successful Weight Loss In Five Easy Steps

Next Post

Meditation Yoga Center

Leave a Reply

0 Shares
Tweet
Share
Share
Pin