Brown fat found to be at the root of cancer-related wasting syndrome

Many patients with advanced stages of cancer, AIDS, tuberculosis, and other diseases die from a condition called cachexia, which is characterized as a “wasting” syndrome that causes extreme thinness with muscle weakness. Cachexia is the direct cause of roughly 20% of deaths in cancer patients. While boosting food intake doesn’t help, and no effective therapies are available, new research in the Cell Press journal Cell Metabolism points to a promising strategy that may stimulate weight gain and muscle strength.

The research relates to a process that has been gaining considerable attention as a way to combat obesity: the browning of white fat. While white fat normally stores calories, brown fat burns them and generates heat in the process. Therefore, efforts to turn white fat into brown fat may help people lose weight.

Erwin Wagner, of the Spanish National Cancer Research Centre in Madrid, and his colleagues found that in mice and patients with cancer-associated cachexia, white fat undergoes significant changes and turns into calorie-burning brown fat. The transformation leads to increased energy consumption and organ wasting.

The team also discovered that inflammation plays an important role in turning white fat into brown fat during cancer-associated cachexia, which suggests a potential therapeutic target. Indeed, anti-inflammatory therapies, including the nonsteroidal anti-inflammatory drug (NSAID) Sulindac, ameliorated the severity of cachexia in mice.

“Our data suggest that inhibition of the browning of white fat represents a promising approach to ameliorate the severity of cachexia in cancer patients,” says Dr. Wagner. “In addition, identifying biomarkers of browning at early stages of cancer development could help to predict which patients are going to develop cachexia and are good candidates to benefit from a preventive treatment.”

Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.

Original story here.
Diet And Weight Loss News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com) <p> <p>[wpramazon asin=”B001RO8IOI”]

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    • Vaguedreams
    • July 18, 2014
    53 of 54 people found the following review helpful
    4.0 out of 5 stars
    Excellent Product 4.5 stars, December 25, 2010
    Vaguedreams (California) –

    Verified Purchase(What’s this?)
    This review is from: OrbiTape Body Mass Tape Measure (Misc.)
    I ordered this device in order to assist me in accurately measuring my body after reading about it in the 4 hour body book.

    I found the product to be exactly as described and extremely easy to use for measuring accurately, quickly, and easily. The product shipped quickly, and was an excellent price. At the time I ordered they were on special for five dollars, but I would easily pay double that, it’s just that convenient.

    A regular measuring tape works fine mind you, again, this is just more of a convenience item. There are a few things that stop this from being a perfect product for me, but they are all fairly minor.

    1.) The Nub that locks the tape into a loop can slide out fairly easily. It would be nice if it had a slightly tighter fit so it would not slide off during a measurement. It is easily resolved by adjusting how you do things, but it’s a slight irritation.

    2.) The tape does not lock at any point like a regular measuring tape. What this means is that you can’t lock the tape and take it off to look at an accurate measurement. Honestly, this is very minor because all it means is that you need to get the reading while it is on you. This is what it was designed for though and it only bothered me when attempting to see my waist measurement.

    3.) The biggest gripe in my opinion, and the only one that really marks it down for me is that for the extremely obese (like myself) the tape is not long enough to get an accurate measurement around my body. For most, this is a non-factor, but for me it stops me from easily measuring my waist. If the tape was just a few inches longer this would not be a factor. It’s a small hindrance though and there is no one else to blame but myself, but it stops it from being absolutely perfect for me.


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    • Amazon Customer
    • July 18, 2014
    31 of 33 people found the following review helpful
    5.0 out of 5 stars
    Simple to use, accurate, nice design, January 12, 2011
    Amazon Customer (Broomfield, CO USA) –

    Verified Purchase(What’s this?)
    This review is from: OrbiTape Body Mass Tape Measure (Misc.)
    Very simple to use, very reliable. Nice design. Easy to read even if you have bifocals or other issues with reading it on your body.

    * Wrap the tape somewhat loosely around the desired body part, placing the nub into the hole it goes into.
    * Press the star button to get it to retract to a constant tension. Release the star button.
    * Remove the nub from the hole you put it into – without pressing the star. The reading is now locked in.
    * Put the tape up to where you can read it – the tape will stay locked – if you don’t press the star.

    You can now read the circumference of whatever just wrapped it around – provided it’s between about 6 inches and 60 inches.


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