2014/05/72ff7_fitness_417p3e5Bh0L._SL160_

Lean patients with fatty liver disease have higher mortality rate

Despite being of a healthier weight, lean patients with nonalcoholic fatty liver disease (NAFLD) have a higher overall mortality rate than patients with NAFLD who are overweight or obese, according to new research presented today at Digestive Disease Week® (DDW). In addition to finding higher mortality rates, an international team of researchers found that lean patients [a body mass index (BMI) less than 25] with NAFLD were more likely to be male, non-Caucasian and to have lower rates of chronic conditions, such as diabetes and hypertension.

“Our comparison of lean patients and their overweight or obese counterparts gives us clues about risk factors for this disease that go beyond a person’s weight,” said Paul Angulo, MD, section chief of hepatology in the division of digestive diseases and nutrition at the University of Kentucky Medical Center. “These findings have implications both for future research and for current standards of care. We must not assume that patients of relatively healthy weight can’t have fatty liver disease.”

The retrospective study is the first of its kind in detailing the characteristics of a large number of lean patients with NAFLD. The study examined more than 20 years’ worth of clinical and laboratory data of more than 1,000 patients with biopsy-confirmed NAFLD. Lean patients had an average BMI of 23 and the non-lean group had an average BMI of 33.

The lean group had significantly less insulin resistance as well as lower levels of a liver enzyme called alanine aminotransferase (ALT) that correlates with liver damage. And while lean patients had a lower degree of fatty deposits on the liver and less advanced fibrosis, these patients showed more severe inflammation of the liver.

Of the 1,090 patients, liver biopsy was done before 2005 in 483 patients. In this subgroup, nine of the 32 (28 percent) lean patients died compared to 62 of the 451 (14 percent) overweight or obese patients. In examining the specific cause of mortality, researchers did not find any differences between the two groups.

“About 30 percent of the U.S. population suffers from NAFLD, and the prevalence of this condition is increasing. Although we often associate fatty liver disease with obese patients, these results suggest that possible signs of liver disease secondary to NAFLD in lean patients should be taken very seriously,” said Dr. Angulo.

Dr. Angulo and his team plan to expand on their findings about this specific patient population by examining data beyond BMI, including fat distribution and differences in cell signaling proteins, such as cytokine and adipokine profiles. They also plan to include patients who have not yet had a liver biopsy.

Story Source:

The above story is based on materials provided by Digestive Disease Week. Note: Materials may be

… Continue reading here.
Diet And Weight Loss News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com) <p>

Melinda Szabo Junior Women’s Fitness 1st place at IFBB World Juniors and Masters Bodybuilding and Fitness Championships 2012 Budapest Follow me here: https:/…

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Comments

    • femcepsfan
    • May 5, 2014
    Reply

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    125 of 127 people found the following review helpful
    5.0 out of 5 stars
    Great Ball, But There Are Some Things you’ll want to know., June 24, 2012
    By 
    Jeff “Brown Coat” (Pasadena, California United States) –

    Verified Purchase(What’s this?)
    This review is from: Body Sport Fitness Ball (Sports)
    asdfasdfLet me start out by saying this is a really nice ball, but there are definitely a few pieces of information that could be of use to you.

    First things first, the ball does smell pretty strongly at the beginning, but on day one the smell is already dissipating, and in my experience this is very typical (I have a handful of these balls from different manufacturers for chairs at desks around my home) but it does smell like a sort of plasticy petroleum type smell. It will go away, but be prepared for it.

    You get what you pay for with the pump, it is by no means a good pump, but works for the purposes of filling up the ball for the first time, and is nicer than many that I have received with other balls I have purchased because it is a foot pump rather than a hand pump, which my arms could not have been happier about. A simple trick to make life a bit easier is to superglue the hoses into position so they stop popping off; once I did this it was a simple matter to finish inflating the ball.
    The ball is EXTREMELY hard when filled to the appropriate size (the size indicated by the measuring tape); the whole time I was filling it, I felt like it would burst but it handled the pressure like a champ (one member of my family ways over 300 lbs and didn’t seem to be taxing the ball at all). This is great if you need a nice hard surface to work out on, but if you want a bit softer of a seat or feel to it then go up a size and let some air out.

    The surface is the shiny smooth one rather than the textured one. I don’t personally care which one I have, but if you want a specific texture, realize that this is the smooth one and might not be the perfect solution for hardwood floors (though I’m using mine on hardwood and it seems to be doing just fine.

    While the description on Amazon says that the ball will hold 1000 lbs of pressure, the materials included in the packaging clearly indicated 600 as the max. I’m having trouble thinking of a situation where 600 lbs wouldn’t cut it, but again, forewarned is forearmed.

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    • Mainiac
    • May 5, 2014
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    54 of 59 people found the following review helpful
    5.0 out of 5 stars
    Huge! Blue!, September 15, 2008
    By 
    Mainiac (Portland, Maine, USA) –

    Verified Purchase(What’s this?)
    This review is from: Body Sport Fitness Ball (Sports)
    Got this to be an occasional desk chair; the 75cm balls are just too short for that for me. It’s huge and sturdy and a wonderful shade of blue. (Blue with a touch of green; I wouldn’t quite call it “teal” myself. Dark turquoise, maybe.)

    It’s just what I wanted.

    p.s. In case this is helpful. I’m 5’10”, but have long legs… I usually wear a 34 or 35″ inseam. Just in case that helps you figure out how large a ball you might like. That is, if you’re going to sit on it. I think this is bigger than I’m supposed to have for an exercise ball if I were using it for that purpose.

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    • Amazon Customer "kruzinom"
    • May 5, 2014
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    37 of 39 people found the following review helpful
    4.0 out of 5 stars
    Wiggle while you work!, June 18, 2009
    By 
    Amazon Customer “kruzinom” (New Hampshire) –

    Verified Purchase(What’s this?)
    I have to say, the thought of sitting on a ball while working at my computer was a little “weird” at first, but let me tell ya, I’m a bit on the hyper side and being able to move around and not sit still all day – LOVE IT!!

    The pump is cheap..but it worked! Love the ball.

    I’m 5’10” and got the extra large. Probably could’ve gone with the large..but what the heck!

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