A new genetic finding from Duke Medicine suggests that some people who are prone to hostility, anxiety and depression might also be hard-wired to gain weight when exposed to chronic stress, leading to diabetes and heart disease.
An estimated 13 percent of people, all of whom are Caucasian, might carry the genetic susceptibility, and knowing this could help them reduce heart disease with simple interventions such as a healthy diet, exercise and stress management.
“Genetic susceptibility, psychosocial stress and metabolic factors act in combination to increase the risk of cardiovascular disease,” said Elizabeth Hauser, Ph.D. director of Computational Biology at the Duke Molecular Physiology Institute. Hauser is senior author of a study detailing the findings in the Oct. 1, 2014, online issue of the European Journal of Human Genetics.
Hauser and colleagues analyzed genome-wide association data from nearly 6,000 people enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA). The MESA study began in 2000 to better understand how heart disease starts, compiling the participants’ genetic makeup as well as physical traits such as hip circumference, body mass index, cholesterol readings, glucose levels, blood pressure and other measures.
In the Duke analysis, the researchers first pinpointed a strong correlation between participants who reported high levels of chronic life stress factors and increased central obesity, as measured by hip circumference.
They then tested genetic variations across the genome to see which ones, in combination with stress, seemed to have the biggest influence on hip circumference. It turns out that variations called single-nucleotide polymorphisms (SNPs) in the EBF1 gene showed a strong relationship with hip circumference, depending on levels of chronic psychosocial stress. What’s more, among those with this particular genotype, hips grew wider as stress levels increased.
“With further analysis, we found a significant pathway from high chronic life stress to wide hip circumference, to high blood glucose and diabetes, to increased cardiovascular disease, notably atherosclerosis,” said Abanish Singh, Ph.D., a researcher in computational biology at Duke and the study’s lead author. “But we found this only in people who were carriers of the EBF1 single-nucleotide polymorphism, and this was limited to participants who were white.”
The researchers reproduced their findings using data from another study, the Framingham Offspring Cohort.
“These findings suggest that a stress reduction intervention, along with diet and exercise, could reduce the risk of cardiovascular disease and may be most effective in individuals with this specific genotype,” said Redford Williams, M.D. one of the study’s senior authors and director of Duke’s Behavioral Medicine Research Center.
Further studies will focus on additional genetic factors and why there might be differences in the genetic factors among racial/ethnic groups, including African-Americans, Hispanics and Asians.
“We need to figure out how these genetic factors influence the increased accumulation of fat in the central body and increased blood glucose levels in persons exposed to high life
… Continue reading here.
Diet And Weight Loss News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com)
Street Workout World Championship 2014 organised by WSWCF (www.wswcf.org) and the Moscow Sports Ministry Moscomsport in collaboration with Kenguru Pro, Barzt…
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+Emin Fejzagic
actually the resultlist I posted was incorrect. Nik came in 5th. The
judging system is pretty straight forward now. Different judges judge one
specific criteria (Static, Dynamic, Combinations), and do not give overall
points. Strong single moves will give you high points in one category, but
to get a all over high score you need to be great in all categories. The
system is certainly not perfect yet but it is going into a good direction
and if anyone has suggestions as to how to improve it I’m certain an email
to wswcf will be well received.
A thing that you do not see in the videos, is that these big events are
really not about who wins or loses. Ask any of the participants or guests
about what they most cherish from those days and most likely you’ll notice
that everyone just had a great time, encouraged each other, friendships
were made as well as plans to further develop the sport.
Street Workout World Championship 2014 in Moscow! 67 athletes from 48
countries! We hope you guys enjoy the video of this EPIC event! Let us know
what you think ;)
song at 7:41 ?
Name of first song ??
what music
4:17 -> sound ??
i have one question! i wanna improve my skill and also wanna gain muscle,
so how often should i train?
thanks
hey there:) this is really amazing:) id like to ask on behalf of people
like me watching this, wondering how on earth i could even get started to
get to even half of what those guys are doing. any references to workouts
for beginners or advice from anyone who are pros or already doing these
moves would be great:) much appreciated:)
what’s song starts from 7:40?
Dose everyone know? please
5.58 Armeniaaaaa
Name of songs ?? First and two
3:48 Brazil!
Is that Dejan Stipic on photo doing full planche?
someone gives me the list, please
y el mejor del mundo ? sadkov? donde esta??
5:52 this is EMINEM !
Hey!! Sorry but where is vladimir sadkov?
Sick Video! Respect from New York!
Energy without the twitchiness,
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Awesome product!,
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Improve Your Workout,
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