Two years ago, the parents of Chloe Olivarez watched painfully as their daughter experienced epileptic seizures hundreds of times a day. The seizures, caused by a rare metabolic disease that depleted her brain of needed glucose, left Chloe nearly unresponsive, and slow to develop.
Within hours, treatment with an edible oil dramatically reduced the number of seizures for then-4-year-old Chloe, one of 14 participants in a small UT Southwestern Medical Center clinical trial.
“Immediately we noticed fewer seizures. From the Chloe we knew two years ago to today, this is a completely different child. She has done amazingly well,” said Brandi Olivarez, Chloe’s mother.
For Chloe and the other trial participants who suffer from the disease called Glut1 deficiency (G1D), seizure frequency declined significantly. Most showed a rapid increase in brain metabolism and improved neuropsychological performance, findings that suggested the oil derived from castor beans called triheptanoin, ameliorated the brain glucose-depletion associated with this genetic disorder, which is often undiagnosed.
“This study paves the way for a medical food designation for triheptanoin, thus significantly expanding therapeutic options for many patients,” said Dr. Juan Pascual, Associate Professor of Neurology and Neurotherapeutics, Physiology, and Pediatrics at UT Southwestern and lead author of a study on the findings, published in JAMA Neurology.
For the estimated 38,000 Americans suffering from this disease, the only proven treatment has been a high-fat ketogenic diet, which only works for about two-thirds of patients. In addition, this diet carries long-term risks, such as development of kidney stones and metabolic abnormalities.
Based on the results of this trial, triheptanoin appears to work as efficiently as the ketogenic diet; however, more research needs to be done before the oil is made available as a medical food therapy, researchers said.
“Triheptanoin byproducts produced in the liver and also in the brain refill brain chemicals that we found are preferentially diminished in the disorder, and this effect is precisely what defines a medical food rather than a drug,” said Dr. Pascual, who heads UT Southwestern’s Rare Brain Disorders Program, maintains an appointment in the Eugene McDermott Center for Human Growth and Development, and holds The Once Upon a Time Foundation Professorship in Pediatric Neurologic Diseases.
The oil, approved for use in research only, is an ingredient in some cosmetic products and is added to butter in some European countries. It is not commercially available in the U.S. for clinical use.
Triheptanoin’s success as an experimental treatment for other metabolic diseases, along with preclinical success in G1D mice, led Dr. Pascual and his trial collaborator, Dr. Charles Roe, Clinical Professor of Neurology and Neurotherapeutics, to first conceive the idea and then launch this trial for G1D patients. The 14 pediatric and adult patients in the study consumed varying amounts of the oil, based on their body weight, four times a day. Given the trial’s success,
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Yoga Body: The Origins of Modern Posture Practice
Yoga is so prevalent in the modern world–practiced by pop stars, taught in schools, and offered in yoga centers, health clubs, and even shopping malls–that we take its presence, and its meaning, for granted. But how did the current yoga boom happen? And is it really rooted in ancient Indian
practices, as many of its adherents claim?
In this groundbreaking book, Mark Singleton calls into question many commonly held beliefs about the nature and origins of postural yoga (asana) and suggests a radically new way of understanding the meaning of yoga as it is practiced by millions of people across the world today. Singleton shows
that, contrary to popular belief, there is no evidence in the Indian tradition for the kind of health and fitness-oriented asana practice that dominates the global yoga scene of the twenty-first century. Singleton''s surprising – and surely controversial – thesis is that yoga as it is popularly
practiced today owes a greater debt to modern Indian nationalism and, even more surprisingly, to the spiritual aspirations of European bodybuilding and early 20th-century women''s gymnastic movements of Europe and America, than it does to any ancient Indian yoga tradition. This discovery enables
Singleton to explain, as no one has done before, how the most prevalent forms of postural yoga, like Ashtanga, Bikram and Hatha yoga, came to be the hugely popular phenomena they are today.
Drawing on a wealth of rare documents from archives in India, the UK and the USA, as well as interviews with the few remaining, now very elderly figures in the 1930s Mysore asana revival, Yoga Body turns the conventional wisdom about yoga on its head.
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Price: 21.95
GAT Muscle Martini Amino Acid Drink, Watermelon, 365 g
Dietary Supplement New Formula! br Award-Winning Taste! Specialty Recovery Anti-Catabolic Health Drink 2 Stimulant Free 3 Absorbs Fast 4 Tastes Delicious 5 Amino Acid Drink 6 Used for Bodybuilding and Athletics 7 Carbs 3, Sugars 0, Calories 12 8 All Natural Colors Sweeteners 9 From the Makers of Jetfuel 10 High Potency BCAAs – 2:1 Ratio! 11 The Athletes Beverage Muscle Martini Contains: Essential amino acids and BCAAs contains highly absorbable EAAs, BCAAs in ratios esigned to promote quality muscle size and strength. 2 Adaptogenic herbs designed to reduce cortisol, increase energy and help combat emotional eating. 3 Beet powder – A source of anti-inflammatory pigments known as betalains, and nitric oxide precursors known as nitrates, beet powder supports vasodilation, pumps, and recovery of joint tissue. 4 A patented antioxidant with 17x t
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Top 4 Nutrition Predictions in the New Year
Several food and nutrition trends were in the spotlight this year, including the continued rise of plant-based diets, non-dairy ice creams and superfoods that are blasts from the past — legumes, apples and cabbage. It can be easy to experience nutrition whiplash in the New Year, but don’t be a victim. Get a jump-start on […]
5 Ways to Feel Good While Getting Fit
Setting intentions is a powerful thing. Then when you have that shiny new gym membership in hand, you feel like nothing stands between you and your goals to get in shape once and for all. Trouble is, lack of motivation, unpreparedness and busy schedules have a way of interfering with our plans. If you find […]
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Fitbit Wireless Activity Cargo HR Wristband, Black, Small
See if you agree with the following statement. Fat loss and weight loss are essentially the same thing, interchangeable. If, like many people, said yes, you guessed wrong. Fat loss and weight loss are not the same thing at all. In fact, they are not even close. If you browse the diet book section of […]
Good work Nick!
Nick, can you pleas tell me how I can find the first speach? It would be
really great if you tell me, becouse I cant find it
perfect!
Wow.. Nick (well I think your name is Nick), this is just your second video
and I think that you ARE allready one of the best bodybuilding motivation
channels on youtube..
Cheers my friend, I hope to see more of your masterpices soon, its really
amazing to watch!
Cenaaa !! ;D
First music
Two Steps From Hell – Blood of The Titan
Thanks for this amazing motivation! BRAVO
Good one man!!
Check out ours, too ;)
Just came home from the gym.. now i’m fucking motivated to go back again.
Jim rohn fuckin epic!!
awesome man, one of the best motivational videos out there