At a time when obesity, type 2 diabetes, and their complications are a veritable epidemic worldwide, researchers at the University of Montreal and CHUM Research Centre (CRCHUM) recently demonstrated the potential of retinoic acid (RA), a derivative of Vitamin A, in treating obesity and type 2 diabetes and preventing their cardiovascular complications. The findings were presented June 6, 2014 at the Annual Conference of the Canadian Nutrition Society in Saint John’s, Newfoundland.
“In obese and insulin resistant mice, retinoic acid reduces the risk of cardiac apoptosis, stimulates the expression of cardio-protective genes reduced by the disease, and protects against the accumulation of collagen in the cardiac muscle, thus avoiding the occurrence of fibrosis and possible associated future complications,” says the first author of the study, Daniel-Constantin Manolescu. Apoptosis is the process of programmed cell death. The discovery follows other research conducted by his team on the effects of RA on insulin resistance, diabetes, and obesity. “Blood glucose, insulin resistance, body weight, and adipocyte size were significantly decreased in treated animals, including abdominal fat, while dietary intake and physical activity were similar for treated or non-treated animals. This suggests an increase in basal energy expenditure,” says Manolescu. White fat is an energy reserve formed by the accumulation of fat in the form of triglycerides to meet unexpected increases in energy costs, but it is also a hormonal tissue with a delicate balance. Overall, if energy intake is greater than expenditures over an extended period, obesity increases, while hormonal balance and energy metabolism are disturbed. In this context, resistance to type 2 diabetes develops over time.
Brown fat also stores triglycerides, but it has the ability to produce heat. Abundant in babies, brown fat does not disappear completely in adulthood. It is irrigated by blood vessels and has many mitochondria, the energy factories of cells. Vitamin A derivatives stimulate a mitochondrial uncoupling protein (UCP1) that allows uncoupling of the mitochondria pathway (oxidative phosphorylation ), which uses energy from the oxidation of nutrients for the production of adenosine triphosphate (ATP). For a period of time, they generate heat (thermogenesis) instead of ATP, which is traditionally the energy required for active metabolism. Exposure to cold leads to the stimulation of brown fat and white fat, promoting the conversion of triglycerides to free fatty acids and glycerol. However, in brown adipocytes, these fatty acids are rapidly oxidized in the mitochondria and produce heat (under the influence of the UCP1 protein). Brown fat thus helps to increase basal energy metabolism. As a result, hibernating mammals fatten in the fall without developing diabetes and lose weight without moving too much in the winter (while warming their den). They are also the animals that accumulate the most Vitamin A in their livers. Retinoic acid (a Vitamin A derivative) is recognized for its involvement in cell maturation and differentiation and may guide pre-adipocytes to become brown (or beige) instead of white. It is as if “boilers” were installed directly in reserves of white fat to
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Fitness News — Sciencedaily
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Science has shown that your current body have the ability to heal sciatica
naturally, without the need for any synthetic medicines, suffer from
hurting surgical treatment, or even changing your diet.
Nope, not even closely feasible. The pain in my leg is quite unbearable but
walking seems to help. It hurts and is awkward at first but the longer the
walk and increasing my gait stride helps. After my walk the pain is almost
non existant.
, try getting into yoga, it helps a whole lot!!
Oh my lord,my pain is intense,I’m trying these poses,thank you for sharing,
my pain is down the left leg and it’s very uncomfortable ,I can’t go on
much longer like this,Tylenol and robax help a bit but I want this to go
now, to all you. Suffering from this, you have my. Compassion and wish your
pain will pass soon, thanks …
@Diegon *Who Else Wants To Learn How To Relieve Their Pain And Discomfort
From Sciatica in 7 Days (Or Less) – Guaranteed?*
+Erica Zienowicz After only 32 minutes, I feel great relief from the
*Sciatica* I have endured for the last 6 months. I expect a full recovery
and look forward to resuming my active lifestyle.
sorry to say but this exercises not great for the people who exsperienced
pain in LB or Buttock or leg ( sciatica) I just agree with knee pulling to
the chest! The other on the back with legs up not good to lift up both legs
together causing pain in back more, or last bending forward even worst.
Sorry
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TY for this, I got sciatica in one day, must have been the slipping of the
nerve root, its only got worse in the last 3 months, ive never had anything
that never healed before, im dying in pain and slowly loosing my mind
battling the pain & stress this causes. Time to educate myself and develop
a hardcore physical plan on exercises & stretches. Im praying to god I can
reverse this condition! :(
I literally can not do that last one.. fml
This is the exercise that my physical therapist suggested to be done a few
times everyday. I has helped tremendously.Between the procedures the
therapist did and this exercise I am pain free now.
Finding a few exercises that work for you will help you manage pain caused
by sciatica.
1 Minute Sciatica Exercises
Hooefully this will ease my pain and allow me to heal. I’m just only 17
years old. Having this pain for a few months now
handy to have on hand,
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Works just fine,
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