mutations
Evolutionary principles used to model cancer mutations, discover potential therapeutic targets
Moffitt Cancer Center researchers are taking a unique approach to understanding and investigating cancer by utilizing evolutionary principles and computational modeling to examine the role of specific genetic mutations in the Darwinian struggle among tumor and normal cells during cancer growth. Cells become malignant by acquiring genetic mutations that lead to increased survival and reproduction. […]
‘Master regulator’ of obesity? Distant IRX3 gene appears to interact with obesity-related FTO gene mutations
Mutations within the gene FTO have been implicated as the strongest genetic determinant of obesity risk in humans, but the mechanism behind this link remained unknown. Now, an international team of scientists has discovered that the obesity-associated elements within FTO interact with IRX3, a distant gene on the genome that appears to be the functional […]