Calorie restriction has long been studied as a way to extend lifespan in animals. It has been associated with the ability to reduce the risks of cardiovascular and other diseases and to improve overall health. Now, researchers at Chang Gung University in Taiwan have found that calorie restriction can also be beneficial to muscles, improving muscle metabolism and mass at an important time — during middle age. The article “Late-onset Caloric Restriction Alters Skeletal Muscle Metabolism by Modulating Pyruvate Metabolism” is published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism.
“To date, caloric restriction (CR) is the only non-pharmaceutical and non-genetic strategy that increases the lifespan of animals and provides health benefits,” the research team wrote. “Regarding skeletal muscle, an organ that is critical for movement and fuel metabolism, studies have reported that CR attenuates age-related muscle loss.”
Calorie restriction is thought to have a protective effect on muscle cells and may help cells better use antioxidants, avoid damage caused by free radicals and function better. While studies that observed the effects of lifelong calorie restriction have shown mixed results in animals of different ages, recent studies have suggested that age may play a role in how CR affects individual animals. The research team hypothesized that because CR can help reprogram metabolism, the most benefit can be reaped from aging muscles in which cellular metabolism is impaired.
Researchers focused on two pathways that produce energy in muscles, glycolysis (sugar metabolism) and mitochondrial oxidative phosphorylation (OXPHOS) in both young and middle-aged rats that were fed a normal diet or a calorie-restricted diet. In the 14-week study, rats on the calorie-restricted diet received 10 percent calorie restriction in the first week, 25 percent restriction in the second and 40 percent restriction for the remaining 12 weeks. The control rats received no calorie restriction. After 14 weeks, the researchers studied changes in the rats’ muscles.
“We investigated whether CR reprogrammed muscle metabolism and whether this improvement was associated with the observed increase in muscle mass. In addition, we examined whether the CR-induced changes were age-dependent,” the researchers wrote.
Not surprisingly, the middle-aged rats had less muscle mass than the young rats did. However, while 14 weeks of calorie restriction did not significantly affect the middle-aged rats, it reduced muscle mass in the young rats. Calorie restriction slowed the glycolytic rate in the muscles and increased the cells’ dependency for OXPHOS versus glycolysis in older rats, which was linked to improvement of normalized muscle mass. The team also found that “14 weeks of CR reprogrammed cellular metabolism, where the relative contribution of OXPHOS and glycolysis in muscles of middle-aged rats with CR was similar to that in muscles of young rats.”
The above story is based on materials provided by <
… Continue reading here.
Diet And Weight Loss News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com)
FREE INSTANT ACCESS: http://go.vincedelmontefitness.com/go/611781/yt-mcs1-tease1&vtid=youtube Download my “3 Advanced Techniques” FREE eBook: …
Video Rating: 4 / 5
Skirt Sports Tough Chick Shirt – Zip Neck, Long Sleeve (For Women)
CLOSEOUTS. With a stretchy, performance-rated design, layer-friendly zip neck and handy thumbhole loop cuffs, Skirt Sportsand#39; Tough Chick shirt certainly lives up to its name. Available Colors: BLACK, CELEBRATION PRINT, UNTAMED PRINT, SANGRIA/ABERDEEN PRINT, WILDER PRINT. Sizes: XS, S, M, L, XL, 2XS, 2XL.
Sold by Sierra Trading Post
Empower Fitness MP-3106R Waist Trimmer Belt Hibiscus Print
Great for water loss and tummy tightening, the Empower Waist Trimmer Belt is designed to preserve body heat, promote water loss, and provide extra back support during exercise. The waist trimmer’s quality neoprene construction makes it comfortable, lightweight, durable, and washable. Its Velcro closure allows for an easy and adjustable fit, with one size fitting most.Promotes weight loss by preserving body heat and stimulating water loss during exerciseVelcro closure provides easy, adjustable fit for most people (comfortably fits up to size 16)Washable, comfortable, light-weight, stretchy fabric stays in place while exercisingSupports back and improves postureIncludes one high-quality 8.5 x 39? neoprene waist trimmer belt
List Price: $ 11.85
Price: $ 11.85
Équipement de protection ( Noir ) poignet/mains Homme
Catégorie:Équipement de protection; Sexe:Homme; Couleur:Noir; Matière:Spandex,Nylon; Poids net (kg):0.1; Saison:Automne; position:mains,poignet
List Price: 7.99
You Can Help Your Child Get More Exercise By Following These 5 Tips
Does your child get enough exercise? You can get your children more active with these 5 fun parenting tips.
Better Health in Four Steps
In just four steps, you can improve your health for the better and this article will show you how. The steps below are bite-sized nuggets of health information you can actually use to live a healthy life. Here we go… Nutritional supplements are the first step As far as I’m concerned, they are very important […]
Top 4 Nutrition Predictions in the New Year
Several food and nutrition trends were in the spotlight this year, including the continued rise of plant-based diets, non-dairy ice creams and superfoods that are blasts from the past — legumes, apples and cabbage. It can be easy to experience nutrition whiplash in the New Year, but don’t be a victim. Get a jump-start on […]
Want to lose weight? Research proves a big breakfast is the first step
If you want to lose weight, you’re not alone. More than half of Americans desire to shed pounds, according to Gallup. This goal inspires people to take action in many ways, from increasing exercise to modifying meals. One thing many people do is skip breakfast in order to lower calorie intake. While this may seem […]
Are you an ACTION TAKER that is ready to build more muscle? Make more
money? And become a better man? Then you’ll want to see this!
Massive thank you to Vince. For sharing some of his wealth of knowledge on
these 3days. I personally took a bucket load of information away.
I can’t wait to see all of my fellow Del Monte Pro Team brothers kick some
This film is going to be very inspirational to those who wish to transform
3 days? Is that what the transformation was at 44 seconds in (before and
You are going to want to pay attention to this, it’s going to be very
inspirational and mind blowing.
You should do one in the California bay area
From skinny to roids
So proud of all your guys! You all look amazing!
… function well with my Note 4 – but overall great for my purpose,
Was this review helpful to you?
Did not work.,
Was this review helpful to you?
As a gift,
Was this review helpful to you?