When we think of ill effects from lead exposure various neurologic problems usually come to mind. Now researchers at the University of Michigan say another health impact can be added to the list: obesity.
Even at low levels, lead is associated with obesity in mice whose mothers were exposed to the chemical, researchers at the U-M School of Public Health found. Specifically male mice exposed to lead had an 8-10 percent increase in weight.
“The data support the obesogen hypothesis that toxicant exposures in the womb contribute to the higher rate of obesity,” said Dana Dolinoy, the John G. Searle Assistant Professor of Environmental Health Sciences and senior author of the study. “There are certain chemicals that are considered the hallmarks of the obesity epidemic, and lead has not been not one of them.”
The closest previous research has come to tying lead exposure to weight are studies showing decreased fetal and early childhood growth in human infants, and obesity in later life in mice. But the U-M study is the first to look at how what a mother ingests, even before pregnancy, impacts her offspring. Scientists like Dolinoy and those in her lab have found that the crucial beginning of life often is where chemical exposure is most impactful.
The U-M paper, “Perinatal Lead (Pb) Exposure Results in Sex-Specific Effects on Food Intake, Fat, Weight and Insulin Response across the Murine Life-Course,” is published in the current issue of PLOS-ONE.
In the study, mothers were exposed to lead through drinking water two weeks before mating then throughout pregnancy and nursing. Their litters were then measured at 3, 6 and 9 months of age for energy expenditure, spontaneous activity, food intake, and body weight and composition. At age 9 months they were tested for glucose tolerance. Researchers determined sex specific impacts on all of the measures.
The groups of mice were exposed to lead at 0.0 parts per million (ppm) for the control group, 2.1ppm, 16ppm or 32ppm. Maternal blood lead levels (BLL) tested at weaning were below the level of detection for the control group, 4.1 (±1.3) micrograms per deciliter (μg/dL), 25.1 (±7.3) μg/dL and 32.1 (±11.4) μg/dL, respectively.
The Centers for Disease Control and Prevention has established a reference level of 5 μg/dL to identify children who have been exposed to lead and require case management. Yet, no safe BLL in children has been identified.
The researchers found:
- Starting in early life, males in the two highest exposure groups outweighed the controls, a trend consistent from youth to adulthood.
- An increase in body fat at all dosages showed up in males at 3 months of age.
- Overall, both sexes exposed to the highest dose ate more than the control group, with males eating more at 6 months of age and female consumption increasing at 9 months of age.
- Exposed males showed impaired insulin levels at 9 months
10% Mehr Leistung im Gym mit: http://goo.gl/DscSmE ▻ Dabei 5% sparen mit Gutscheincode RTG5 auf deine volle Bestellung! ▻ JIL: http://youtu.be/07FFxik_1us ▻ SAI: http://youtu.be/K2_RWYK_…
Video Rating: 4 / 5
TIRED OF LOGGING HOURS AT THE GYM AND NOT GETTING RESULTS?WANT TO EAT DELICIOUS FOODS AND STILL LOSE WEIGHT?SHAKE THINGS UP AND SLIM DOWN WITH THE WEIGHT LOSS PHENOMENON THAT''S TAKING THE COUNTRY BY STORM…ZUMBA!Created by celebrity fitness trainer Beto Perez, Zumba(r) combines fun, easy-to-follow dance steps with hot Latin beats to help you shed pounds and inches fast. Now the DVD and classes that have hooked millions are available in book format, with a complete workout program, fat-burning diet, as well as a DVD with a 5-minute instructional demo that shows the basic moves you''ll need to learn plus 60 minutes worth of music to help you Zumba your way to the perfect body. Using the principles of interval and resistance training, the simple dance and sculpting moves (inspired by the traditional cumbia, salsa, samba, and merengue) tone and shape your body. And because it burns 600 to 1,000 calories per hour, you don''t have to restrict your meals to boring or bland-tasting diet foods. The Zumba diet begins with a 5-Day Express Diet to jump start weight loss (lose up to 9 lbs in 5 days) and then offers 14-day meal plans and recipes that target weight loss in the stomach and thighs. You''ll find:* Hot moves that make you feel like you''re on the dance floor-not on the elliptical machine!* Recipes for mouthwatering meals that boost your metabolism* Dozens of workout combinations so you never get bored* An exclusive jump-start program to get you ready for that big event next weekend* An easy plan to help you keep up your progress and maintain the weight loss So start moving, grooving and losing with Zumba today!
Honey Caramel 15g Protein 1 7g Fiber 4 Gluten Free 3 No Artificial Flavors or Colors Life requires protein, but we know it s hard to get lean protein. That s why we make delicious products without all the sugar, fat and calories, to give you energy you need every day. So whether you missed breakfast, have the 3 o clock hunger pang or need to refuel after a workout, we give you the protein you need, when you need it. 6 – 1.83 oz Bars ~ Total Net Wt. 10.98 oz 888-836-8977
Price: $ 9.99
Sold by drugstore.com[wpramazon asin=”B00IKPI1IU”]
Does your child get enough exercise? You can get your children more active with these 5 fun parenting tips.
In just four steps, you can improve your health for the better and this article will show you how. The steps below are bite-sized nuggets of health information you can actually use to live a healthy life. Here we go… Nutritional supplements are the first step As far as I’m concerned, they are very important […]
Several food and nutrition trends were in the spotlight this year, including the continued rise of plant-based diets, non-dairy ice creams and superfoods that are blasts from the past — legumes, apples and cabbage. It can be easy to experience nutrition whiplash in the New Year, but don’t be a victim. Get a jump-start on […]
Setting intentions is a powerful thing. Then when you have that shiny new gym membership in hand, you feel like nothing stands between you and your goals to get in shape once and for all. Trouble is, lack of motivation, unpreparedness and busy schedules have a way of interfering with our plans. If you find […]