Obesity alone does not cause arthritis in animals

The link between obesity and osteoarthritis may be more than just the wear and tear on the skeleton caused by added weight.

A Duke University study has found that the absence of the appetite hormone leptin can determine whether obese mice experience arthritis, no matter how heavy they are.

“We were completely surprised to find that mice that became extremely obese had no arthritis if their bodies didn’t have leptin,” said Farshid Guilak, PhD, director of orthopaedic research in the Duke Department of Surgery.

“Although there was some earlier evidence that leptin might be involved in the arthritis disease process, we didn’t think that there would be no arthritis at all.”

In fact, the joints from the obese mice in the study appearing in the journal Arthritis & Rheumatism looked better than those of the normal control mice, Guilak said. “However, in another study, we found that mice that gained half as much weight on a high-fat diet but processed leptin normally showed significant knee osteoarthritis.”

Leptin influences many of the factors involved in osteoarthritis — body weight, inflammation, sex hormone levels, and bone metabolism, said lead author Tim Griffin, PhD, who was at Duke Orthopaedic Department and now is an assistant member of the Free Radical Biology and Aging Program at the Oklahoma Medical Research Foundation.

“That also makes leptin challenging to study, however, because it’s difficult to isolate which pathway is being altered to prevent the development of osteoarthritis.”

Leptin is a well-known regulator of appetite, but this is the first time scientists have reported a role for leptin as a metabolic link between obesity and altered cartilage metabolism in joints.

The role of obesity as a risk factor for arthritis is well characterized, but it was thought to be merely a case of overloading joints with extra weight.

“It hadn’t been studied beyond that,” Guilak said. “We knew from other studies that obese people got arthritis in their hands, too, which don’t bear weight. This indicated that something besides just body-weight level affected their joints.”

The Duke team set out to learn whether the increased body fat of obesity causes an inflammatory response in joints — an imbalance of the immune system signaling proteins called cytokines and other chemicals in osteoarthritis.

They studied mice that were leptin-deficient or deficient in leptin receptors — mice that didn’t have any effective leptin in their bodies. Both types of mice overate and gained weight.

Then they compared the study mice with normal mice to document knee osteoarthritis. The measurements included pro- and anti-inflammatory cytokines present in arthritis, and several tests to assess bone changes in the knees of the mice.

The knee bones of the leptin-free, obese mice did change, but without forming osteoarthritis. The levels of inflammatory cytokines, which correlate with arthritis, were largely unchanged

… Continue reading here.
Diet And Weight Loss News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com) <p>

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    • Alonso Vargas Rázuri
    • July 12, 2014

    Big E Langston > David Otunga !

    • King D
    • July 12, 2014

    A lot of people dislike David Otunga and wonder why he would be in video
    games & on magazine covers. I would like to remind them David Otunga won
    second place on NXT based on fan votes. Yes David Otunga has fans. I’m a
    David Otunga fan and there are a lot of us.

    • Clocktown Television
    • July 12, 2014

    David Otunga shows you how to get in shape in order to still stink as a
    wrestler in the ring. As a bonus. He gives you the scoop behind the scenes
    behind the scenes where he works off camera because of his failure as a
    wrestler. Get the DVD! 

    • Roi Lion
    • July 12, 2014

    that’s going to be me in a couple years. the physique, not the magazine

    • Alexander Bartlett
    • July 12, 2014

    Hasn’t wrestled since march 

    • July 12, 2014

    so where is he at now ????

    • Adam Acevedo
    • July 12, 2014

    I thought he cut from wwe

    • Double-H215
    • July 12, 2014

    Now, I liked the character that David was playing when he was on NXT. Truth
    be told, if you have to bring a character to life, then your personality
    have to jump in that character. Because the character have to be believable
    in order to come to life.
    With that, what you’re suppose to say, can be said in your way. But, if
    your were to be that character. Example: we all know how the Joker is. In
    1989, the Joker was played by Jack Nicholson. And in 2008, the Joker was
    played by Heath Ledger. 2 guys that have put their spin on the character.
    And no matter how different they were. You knew it was the same character
    they were playing.
    You see the WWE problem is, if they give you a stupid gimmick, you’ll take
    it as a stupid gimmick. But nobody will tell you that you can turn that
    stupid gimmick into something hot. So when they gave David Otunga a new
    gimmick, it didn’t have anything to do with competing in the ring. Which
    make sense why he’s off TV now. Could David Otungo turn that gimmick into a
    competing act? Yes, but he was doing what he was told.

    On another note: Why aren’t acting classes apart of this business yet? It’s
    2013, and y’all still trying to make stars the same way? Who is y’all next
    John Cena? It’s not Punk. And do y’all believe in Bryan?

    • Holistic Apologist
    • July 12, 2014

    Great look, intelligent and I’m sure a nice guy, but he has little charisma
    and below marginal wrestling ability.

    • EntertainmentEC2
    • July 12, 2014

    Otunga is ripped, too bad hes a lawyer. He probably gets off with his

    • xBaconWrestlingx
    • July 12, 2014

    Otunga is still alive?

    • BarbaricGamerNL
    • July 12, 2014

    wait who is david otunga

    • Nikki Wilson
    • July 12, 2014

    On a scale from 1 to JTG. How irrelevant is David Otunga? x)

    • SkyrimXtreme91
    • July 12, 2014

    He’s still employed?

    • deathofdragon61
    • July 12, 2014


    • Rohan Chadha
    • July 12, 2014

    Big show vs Triple h at wrestlemania 30!!

    • Tadpole Jovian
    • July 12, 2014

    They should add like current superstars in 2k14 game I mean like seriously 

    • dietfreeman42718
    • July 12, 2014

    It’s stuff like this or him randomly being put on RAW for one little thing
    that I even remember Otunga is still in WWE. 

    • Cm Lun
    • July 12, 2014


    • Euris Jaquez
    • July 12, 2014

    For Vince it said beginner to learn not to fight cuz he can’t even fight
    like when he vs john cena he called everything cuz he was afraid if losing

    • TheAgent648
    • July 12, 2014

    and still no championships.

    • Chloe Smyth
    • July 12, 2014

    I forgot David Otunga was a thing..

    • Edward Elfigo
    • July 12, 2014

    And that is wath jericho and cm punk cant be best

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