The link between obesity and osteoarthritis may be more than just the wear and tear on the skeleton caused by added weight.
A Duke University study has found that the absence of the appetite hormone leptin can determine whether obese mice experience arthritis, no matter how heavy they are.
“We were completely surprised to find that mice that became extremely obese had no arthritis if their bodies didn’t have leptin,” said Farshid Guilak, PhD, director of orthopaedic research in the Duke Department of Surgery.
“Although there was some earlier evidence that leptin might be involved in the arthritis disease process, we didn’t think that there would be no arthritis at all.”
In fact, the joints from the obese mice in the study appearing in the journal Arthritis & Rheumatism looked better than those of the normal control mice, Guilak said. “However, in another study, we found that mice that gained half as much weight on a high-fat diet but processed leptin normally showed significant knee osteoarthritis.”
Leptin influences many of the factors involved in osteoarthritis — body weight, inflammation, sex hormone levels, and bone metabolism, said lead author Tim Griffin, PhD, who was at Duke Orthopaedic Department and now is an assistant member of the Free Radical Biology and Aging Program at the Oklahoma Medical Research Foundation.
“That also makes leptin challenging to study, however, because it’s difficult to isolate which pathway is being altered to prevent the development of osteoarthritis.”
Leptin is a well-known regulator of appetite, but this is the first time scientists have reported a role for leptin as a metabolic link between obesity and altered cartilage metabolism in joints.
The role of obesity as a risk factor for arthritis is well characterized, but it was thought to be merely a case of overloading joints with extra weight.
“It hadn’t been studied beyond that,” Guilak said. “We knew from other studies that obese people got arthritis in their hands, too, which don’t bear weight. This indicated that something besides just body-weight level affected their joints.”
The Duke team set out to learn whether the increased body fat of obesity causes an inflammatory response in joints — an imbalance of the immune system signaling proteins called cytokines and other chemicals in osteoarthritis.
They studied mice that were leptin-deficient or deficient in leptin receptors — mice that didn’t have any effective leptin in their bodies. Both types of mice overate and gained weight.
Then they compared the study mice with normal mice to document knee osteoarthritis. The measurements included pro- and anti-inflammatory cytokines present in arthritis, and several tests to assess bone changes in the knees of the mice.
The knee bones of the leptin-free, obese mice did change, but without forming osteoarthritis. The levels of inflammatory cytokines, which correlate with arthritis, were largely unchanged
Take a behind the scenes look at David Otunga’s first Muscle & Fitness cover shoot and hear his story about how he got into body building.
Video Rating: 4 / 5
Does your child get enough exercise? You can get your children more active with these 5 fun parenting tips.
In just four steps, you can improve your health for the better and this article will show you how. The steps below are bite-sized nuggets of health information you can actually use to live a healthy life. Here we go… Nutritional supplements are the first step As far as I’m concerned, they are very important […]
Several food and nutrition trends were in the spotlight this year, including the continued rise of plant-based diets, non-dairy ice creams and superfoods that are blasts from the past — legumes, apples and cabbage. It can be easy to experience nutrition whiplash in the New Year, but don’t be a victim. Get a jump-start on […]
Setting intentions is a powerful thing. Then when you have that shiny new gym membership in hand, you feel like nothing stands between you and your goals to get in shape once and for all. Trouble is, lack of motivation, unpreparedness and busy schedules have a way of interfering with our plans. If you find […]