Mechanism could help old muscle grow

Sarcopenia — the significant loss of muscle mass and function that can occur as we age — is associated with many chronic conditions such as diabetes, high cholesterol and obesity. In findings published online ahead of publication in the September 2014 issue of The FASEB Journal, researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University identify a muscle-building mechanism that could be important in addressing sarcopenia.

When people strength train the body responds by making muscle. The researchers recruited 16 healthy but sedentary men to perform a single bout of resistance exercise to trigger muscle growth and examined tissue samples taken before and six hours after the exercise. Half of the men were in their twenties and the other half in their seventies.

“In order for the body to make proteins that build muscle, certain genes need to be turned on,” said lead author Donato A. Rivas, Ph.D., a scientist in the Nutrition, Exercise Physiology and Sarcopenia Laboratory at the USDA HNRCA at Tufts University. “We noticed the older people had a lot fewer genes turned on compared to the younger people, showing us their muscles weren’t responding as well to the exercise.”

Rivas and colleagues observed that the level of microRNAs, small RNA molecules that have a prominent role in regulating genes, was lower in the muscle tissue of the older men, compared to younger men. “One of the steps in building muscle seems to be missing in the older men, preventing them from responding to the exercise as strongly as the younger men did,” Rivas said. “It is possible that the suppression of these microRNAs is setting off a chain of events that is causing older people to be less efficient in developing muscle.”

With the population of older adults in the United States projected to increase significantly in the coming decades, more effective sarcopenia treatment and prevention could help control healthcare costs. “Age-related muscle loss has been associated with a myriad of other health problems,” said senior author Roger A. Fielding, Ph.D., director of the Nutrition, Exercise Physiology and Sarcopenia Laboratory at the USDA HNRCA at Tufts University. “Muscle mass is closely tied to our metabolism and losing it increases the risk of developing metabolic diseases like type 2 diabetes and cardiovascular disease. We also know that a program of moderate physical activity, including resistance exercises, can strongly influence a person’s chances of maintaining their ability to walk after age 70.”

In addition to resistance exercises, scientists are exploring different approaches to preserving and building muscle mass in older adults. “A few studies suggest gene therapy, nutrient supplementation or hormone replacement therapy can assist with building muscle,” said Fielding, who is also a professor at the Friedman School of Nutrition Science and Policy at Tufts University and the Tufts University School of Medicine. “Our identification of a possible microRNA target could help advance the study

… Continue reading here.
Fitness News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com) <p>

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    • Loi Vuitton
    • June 18, 2014

    @madam *Knee pain is one of the most common complaints heard by doctors.
    Learn all about knee pain, including what you can do for yours.*

    • rajib maity
    • June 18, 2014

    Really helpful.

    • Daniel Wu
    • June 18, 2014

    clearly explained and shown

    • Max Greene
    • June 18, 2014

    i solved runners knee ur methods will do nothing to relieve the pressure
    that causes runners knee. it good for a warm up but no sutuon for the root

    • Ashok Borade
    • June 18, 2014

    Thank u so much for this video, hope my pain is relief …..

    • Laurel R
    • June 18, 2014

    I have PFS and these exercises are NOT harmful as so many others can be.
    These are den in PT. If done faithfully and regularly , I believe they
    can help…so tired of seeing videos with someone kneeling for knee pain !

    • nutty ahmed
    • June 18, 2014

    I’m only 12 and I’ve started to get bad knees which pain a lot when I
    walk,mainly because of playing football and getting dirty fouls from

    • Alaric Niemi
    • June 18, 2014

    Thanks! Helped a bit! Ive got knee pain at only 20 years old 🙁 let this be
    a lesson to all you longboarders, wear knee pads! At least when youre
    trying new tricks 

    • Neofran15Vlogs
    • June 18, 2014

    Thank you, I have bad knees and feet, at age 26..this really helps..

    • je187u
    • June 18, 2014


    • Gabrielle Morin
    • June 18, 2014

    Yeah I’m 14 and I already have many issues in my knees due to collapsed
    arches so thank you

    • freaklatino13
    • June 18, 2014

    One of my knees startes to hurt when I was running …when I go to the gym
    I usually run/walk for 30min ..should I stop running?. The pain occurs when
    ever I take a step …but its only in one knee

    • Prime of Life Fitness, LLC
    • June 18, 2014

    Without added resistance, you should be fine to do these exercises daily.
    Be sure to listen to your body, though. If the exercises leave you feeling
    sore or fatigued the following day, you might do better with a rest day in

    • Prime of Life Fitness, LLC
    • June 18, 2014

    You should first check with your doctor to learn the source of your knee
    pain and get his or her advice. Since these exercises don’t involve added
    resistance, you should be free to do them daily without causing injury. The
    best advice is always to listen to your body. If it hurts, back off. Good

    • PT Made Simple
    • June 18, 2014

    Good Video. I have a video about another way of treating knee pain. Please
    check out my video of how to treat knee pain. Youtube channel is PT Made
    Simple Brian Grenda

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