Researchers at the Université Laval Faculty of Medicine, the Quebec Heart and Lung Institute Research Center, and the Institute of Nutrition and Functional Foods have discovered a natural molecule that could be used to treat insulin resistance and type 2 diabetes. The molecule, a derivative of omega-3 fatty acids, mimics some of the effects of physical exercise on blood glucose regulation.
The details of the discovery made by Professor André Marette and his team are published today in Nature Medicine.
It has been known for some time that omega-3 fatty acids can help reduce insulin resistance caused by a diet high in saturated fat. In their earlier work, André Marette and his colleagues had linked these effects to a bioactive lipid called protectin D1. In investigating further, they discovered that another member of the same family named protectin DX (PDX) triggers the production and release of interleukin 6 (IL-6) in muscle cells, a response that also occurs during physical exercise. “Once in the bloodstream, IL-6 controls glucose levels in two ways: it signals to the liver to reduce glucose production and acts directly on the muscles to increase glucose uptake,” explains the researcher who is also Scientific Director of Université Laval’s Institute of Nutrition and Functional Foods.
The researchers used transgenic mice lacking the IL-6 gene to demonstrate the link between PDX and IL-6. PDX had very little effect on the control of blood glucose in these animals. In similar tests conducted on obese diabetic rats, PDX was shown to dramatically improve responsiveness to insulin, the hormone which regulates blood glucose. “The mechanism of action described for PDX represents a new therapeutic strategy for improving glucose control,” proposes the researcher. “Its efficacy may be comparable with that of certain drugs currently prescribed to control glycemia.”
Even though PDX appears to mimic the effect of physical exercise by triggering IL-6 secretion in the muscles, André Marette warns that it is not a substitute for physical activity. “Exercise has cardiovascular and other hormonal benefits that go well beyond its metabolic effects on the muscles,” adds the researcher whose work is supported by the Canadian Institutes of Health Research (CIHR) and the Canadian Diabetes Association.
Professor Marette and Université Laval have filed a patent application for PDX and its therapeutic applications. “For us, the next step is to demonstrate the antidiabetic effects in humans and determine the receptor through which PDX acts.”
In addition to André Marette, the study is authored by Phillip White, Philippe St-Pierre, Alexandre Charbonneau, Patricia Mitchell, Emmanuelle St-Amand, and Bruno Marcotte.
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<p>Question by Dishy: simple daily exercises to stay healthy?
I am rather lazy when it comes to exercising.
Answer by colorofmylife81
Experts recommend that you accumulate one hour of physical activity every day to stay healthy or improve our health. Obviously this is also good if you are trying to lose weight and keeping it off.
The rule is the more intensive the activity is, the shorter the duration of exercise. As you progress into activity with moderate intensity, you can cut down to 30 minutes a day for four days per week.
There are 3 types of exercise that your body needs to keep healthy – cardiovascular, flexibility and strength. Cardiovascular activities are those ranging from moderate to vigorous exercises.
Here are some of the light, moderate and vigorous activities:
Give your answer to this question below!
Does your child get enough exercise? You can get your children more active with these 5 fun parenting tips.
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