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Gene interacts with stress, leads to heart disease in some people

A new genetic finding from Duke Medicine suggests that some people who are prone to hostility, anxiety and depression might also be hard-wired to gain weight when exposed to chronic stress, leading to diabetes and heart disease.

An estimated 13 percent of people, all of whom are Caucasian, might carry the genetic susceptibility, and knowing this could help them reduce heart disease with simple interventions such as a healthy diet, exercise and stress management.

“Genetic susceptibility, psychosocial stress and metabolic factors act in combination to increase the risk of cardiovascular disease,” said Elizabeth Hauser, Ph.D. director of Computational Biology at the Duke Molecular Physiology Institute. Hauser is senior author of a study detailing the findings in the Oct. 1, 2014, online issue of the European Journal of Human Genetics.

Hauser and colleagues analyzed genome-wide association data from nearly 6,000 people enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA). The MESA study began in 2000 to better understand how heart disease starts, compiling the participants’ genetic makeup as well as physical traits such as hip circumference, body mass index, cholesterol readings, glucose levels, blood pressure and other measures.

In the Duke analysis, the researchers first pinpointed a strong correlation between participants who reported high levels of chronic life stress factors and increased central obesity, as measured by hip circumference.

They then tested genetic variations across the genome to see which ones, in combination with stress, seemed to have the biggest influence on hip circumference. It turns out that variations called single-nucleotide polymorphisms (SNPs) in the EBF1 gene showed a strong relationship with hip circumference, depending on levels of chronic psychosocial stress. What’s more, among those with this particular genotype, hips grew wider as stress levels increased.

“With further analysis, we found a significant pathway from high chronic life stress to wide hip circumference, to high blood glucose and diabetes, to increased cardiovascular disease, notably atherosclerosis,” said Abanish Singh, Ph.D., a researcher in computational biology at Duke and the study’s lead author. “But we found this only in people who were carriers of the EBF1 single-nucleotide polymorphism, and this was limited to participants who were white.”

The researchers reproduced their findings using data from another study, the Framingham Offspring Cohort.

“These findings suggest that a stress reduction intervention, along with diet and exercise, could reduce the risk of cardiovascular disease and may be most effective in individuals with this specific genotype,” said Redford Williams, M.D. one of the study’s senior authors and director of Duke’s Behavioral Medicine Research Center.

Further studies will focus on additional genetic factors and why there might be differences in the genetic factors among racial/ethnic groups, including African-Americans, Hispanics and Asians.

“We need to figure out how these genetic factors influence the increased accumulation of fat in the central body and increased blood glucose levels in persons exposed to high life

… Continue reading here.
Diet And Weight Loss News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com)

Street Workout World Championship 2014 organised by WSWCF (www.wswcf.org) and the Moscow Sports Ministry Moscomsport in collaboration with Kenguru Pro, Barzt…

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Comments

    • BaristiWorkout
    • October 7, 2014
    Reply

    +Emin Fejzagic
    actually the resultlist I posted was incorrect. Nik came in 5th. The
    judging system is pretty straight forward now. Different judges judge one
    specific criteria (Static, Dynamic, Combinations), and do not give overall
    points. Strong single moves will give you high points in one category, but
    to get a all over high score you need to be great in all categories. The
    system is certainly not perfect yet but it is going into a good direction
    and if anyone has suggestions as to how to improve it I’m certain an email
    to wswcf will be well received.
    A thing that you do not see in the videos, is that these big events are
    really not about who wins or loses. Ask any of the participants or guests
    about what they most cherish from those days and most likely you’ll notice
    that everyone just had a great time, encouraged each other, friendships
    were made as well as plans to further develop the sport.

    View Comment
    • BaristiWorkout
    • October 7, 2014
    Reply

    Street Workout World Championship 2014 in Moscow! 67 athletes from 48
    countries! We hope you guys enjoy the video of this EPIC event! Let us know
    what you think ;)

    View Comment
    • TeDo Cein
    • October 7, 2014
    Reply

    song at 7:41 ?

    View Comment
    • BarHeroes Cacak
    • October 7, 2014
    Reply

    Name of first song ??

    View Comment
    • László Nagy
    • October 7, 2014
    Reply

    what music

    View Comment
    • Norbert Planka
    • October 7, 2014
    Reply

    4:17 -> sound ??

    View Comment
    • King Nguyen
    • October 7, 2014
    Reply

    i have one question! i wanna improve my skill and also wanna gain muscle,
    so how often should i train?
    thanks

    View Comment
    • Erlinda Shen
    • October 7, 2014
    Reply
    • Mark18Martin
    • October 7, 2014
    Reply

    hey there:) this is really amazing:) id like to ask on behalf of people
    like me watching this, wondering how on earth i could even get started to
    get to even half of what those guys are doing. any references to workouts
    for beginners or advice from anyone who are pros or already doing these
    moves would be great:) much appreciated:)

    View Comment
    • 吳長勳
    • October 7, 2014
    Reply

    what’s song starts from 7:40?
    Dose everyone know? please 

    View Comment
    • Artur Abrahamyan
    • October 7, 2014
    Reply

    5.58 Armeniaaaaa 

    View Comment
    • BarHeroes Cacak
    • October 7, 2014
    Reply

    Name of songs ?? First and two

    View Comment
    • Wesley Ramos Cavalcante Gonçalves'
    • October 7, 2014
    Reply

    3:48 Brazil!

    View Comment
    • Jovan Micic
    • October 7, 2014
    Reply

    Is that Dejan Stipic on photo doing full planche?

    View Comment
    • li hoa
    • October 7, 2014
    Reply

    someone gives me the list, please

    View Comment
    • nicolas gagliardo
    • October 7, 2014
    Reply

    y el mejor del mundo ? sadkov? donde esta??

    View Comment
    • илья целковой
    • October 7, 2014
    Reply

    5:52 this is EMINEM !

    View Comment
    • Nicolas Pley
    • October 7, 2014
    Reply

    Hey!! Sorry but where is vladimir sadkov?

    View Comment
    • gforcebreakin
    • October 7, 2014
    Reply

    Sick Video! Respect from New York!

    View Comment
    • Amazon Customer
    • October 7, 2014
    Reply
    1 of 1 people found the following review helpful
    5.0 out of 5 stars
    Energy without the twitchiness, May 29, 2014
    By 

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    This review is from: Muscle Pharm Assault Pre-Workout System, Grape Blast, 0.96 Pound (Health and Beauty)
    I prefer Assault over NOXplode because NOXplode gives me a sort of anxious, twitchy feeling as though I had too much caffeine sometimes. I don’t get that feeling with Assault, but I get all of the energy.

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    • Atredes
    • October 7, 2014
    Reply
    1 of 1 people found the following review helpful
    5.0 out of 5 stars
    Awesome product!, April 4, 2014
    By 
    Atredes (Boise Idaho) –

    Verified Purchase(What’s this?)
    This review is from: Muscle Pharm Assault Pre-Workout System, Grape Blast, 0.96 Pound (Health and Beauty)
    Can’t say enough good things about this Pre-Workout System. Flavor is great, mixes well, works as described, and most importantly — gets me going and keeps me going longer than without! I would recommend trying the smallest container first. I was really skeptical, but was pleasantly surprised!

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    • Cory Bayless
    • October 7, 2014
    Reply
    1 of 1 people found the following review helpful
    5.0 out of 5 stars
    Improve Your Workout, December 2, 2013
    By 

    Verified Purchase(What’s this?)
    This review is from: Muscle Pharm Assault Pre-Workout System, Grape Blast, 0.96 Pound (Health and Beauty)
    I went through the Lemon-Lime flavor already and wanted to give Grape a shot. I love feeling I get from Assault. Not too jittery, but just enough that makes you want to go throw around some weights and burn off energy. 5:20AM CrossFit workouts suck, but Assault wakes your ass up!

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