Medicine focuses almost entirely on fighting chronic diseases in a piecemeal fashion as symptoms develop. Instead, more efforts should be directed to promoting interventions that have the potential to prevent multiple chronic diseases and extend healthy lifespans.
Researchers writing in the journal Nature say that by treating the metabolic and molecular causes of human aging, it may be possible to help people stay healthy into their 70s and 80s.
In a commentary published July 24 in Nature, a trio of aging experts calls for moving forward with preclinical and clinical strategies that have been shown to delay aging in animals. In addition to promoting a healthy diet and regular exercise, these strategies include slowing the metabolic and molecular causes of human aging, such as the incremental accumulation of cellular damage that occurs over time. The researchers, at Washington University School of Medicine in St. Louis, Brescia University in Italy, the Buck Institute for Aging and Research and the Longevity Institute at the University of Southern California, write that economic incentives in biomedical research and health care reward treating disease more than promoting good health.
“You don’t have to be a mathematician or an economist to understand that our current health care approach is not sustainable,” said first author Luigi Fontana, MD, PhD, professor of medicine and nutrition at Washington University and Brescia University. “As targeting diseases has helped people live longer, they are spending more years being sick with multiple disorders related to aging, and that’s expensive,” said
The diseases of old age — such as heart failure, diabetes, arthritis, cancer and Alzheimer’s disease — tend to come as a package, the researchers write. More than 70 percent of people over age 65 have two or more chronic diseases. But, they noted, studies of diet, genes and drugs indicate that interventions targeted to specific molecular pathways that delay one age-related disease often stave off others, too.
“Heart failure doesn’t happen all at once,” Fontana said. “It takes 30 or 40 years of an unhealthy lifestyle and activation of aging-related pathways from metabolic abnormalities such as high blood pressure, high cholesterol and type 2 diabetes to give a person heart failure in his 60s. So we propose using lifestyle interventions — such as a personalized healthy diet and exercise program — to down-regulate aging pathways so the patient avoids heart failure in the first place.”
His own research has highlighted potential benefits from dietary restriction in extending healthy life span. He has found that people who eat significantly fewer calories, while still getting optimal nutrition, have “younger,” more flexible hearts. They also have significantly lower blood pressure, much less inflammation in their bodies and their skeletal muscles function in ways similar to muscles in people who are significantly younger.
Fontana and his co-authors also point out that several molecular pathways shown to increase longevity in animals also are affected by approved and experimental
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Diet And Weight Loss News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com)
Music by The Verve April 2013 Practice New 40mm x-pole! New Moves Chopper to Butterfly Twisted Grip Shouldermount to Handspring Back Attitude to Lolo Lift Ma…
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You are awesome, love that you are “home schooled” ! I am new to pole
View Commentfitness, gonna get a pole for home, what X-pole do you recommend ? I am
your size. I want an x-pert stationary/spinning modes, but unsure if to
get 45mm or 50mm. Your advice would be greatly appreciated !!!
woow this is really good,how long did it take you to be able to this stage?
View CommentWow, you’re really good, awesome moves and great strength too :-)
View CommentAmazing…
View CommentSo talented!
For Matthew xx
View CommentPolefitness
View CommentDamn you’re good and i would say without hesitation you were a
View Commentprofessional!
Keep working girl! Big respect! <3
Beautiful and graceful! You make me wanne be as good as that. Just started
View Commentthis week. Full of bruises but love it. How long have you been doing this?
wooow girl you rock 🙂 how did you strengthen your arms like that? you are
View Commentamazing :)
HOW
View CommentDAMN GURL
View CommentOMG TEACH ME OMG YOU ARE SO TINY AND PERFECT ILY
View CommentI haven’t seen anyone do this much variety of tricks before. You are a star
View Commentin your own right.
Great until it popped 🙁,
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Fantastic,
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