Brown fat found to be at the root of cancer-related wasting syndrome

Brown fat found to be at the root of cancer-related wasting syndrome

Many patients with advanced stages of cancer, AIDS, tuberculosis, and other diseases die from a condition called cachexia, which is characterized as a “wasting” syndrome that causes extreme thinness with muscle weakness. Cachexia is the direct cause of roughly 20% of deaths in cancer patients. While boosting food intake doesn’t help, and no effective therapies are available, new research in the Cell Press journal Cell Metabolism points to a promising strategy that may stimulate weight gain and muscle strength.

The research relates to a process that has been gaining considerable attention as a way to combat obesity: the browning of white fat. While white fat normally stores calories, brown fat burns them and generates heat in the process. Therefore, efforts to turn white fat into brown fat may help people lose weight.

Fat Loss

Erwin Wagner, of the Spanish National Cancer Research Centre in Madrid, and his colleagues found that in mice and patients with cancer-associated cachexia, white fat undergoes significant changes and turns into calorie-burning brown fat. The transformation leads to increased energy consumption and organ wasting.

The team also discovered that inflammation plays an important role in turning white fat into brown fat during cancer-associated cachexia, which suggests a potential therapeutic target. Indeed, anti-inflammatory therapies, including the nonsteroidal anti-inflammatory drug (NSAID) Sulindac, ameliorated the severity of cachexia in mice.

“Our data suggest that inhibition of the browning of white fat represents a promising approach to ameliorate the severity of cachexia in cancer patients,” says Dr. Wagner. “In addition, identifying biomarkers of browning at early stages of cancer development could help to predict which patients are going to develop cachexia and are good candidates to benefit from a preventive treatment.”

Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.

Original story here.
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    • Vaguedreams
    • July 18, 2014
    53 of 54 people found the following review helpful
    4.0 out of 5 stars
    Excellent Product 4.5 stars, December 25, 2010
    Vaguedreams (California) –

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    This review is from: OrbiTape Body Mass Tape Measure (Misc.)
    I ordered this device in order to assist me in accurately measuring my body after reading about it in the 4 hour body book.

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    • Amazon Customer
    • July 18, 2014
    31 of 33 people found the following review helpful
    5.0 out of 5 stars
    Simple to use, accurate, nice design, January 12, 2011
    Amazon Customer (Broomfield, CO USA) –

    Verified Purchase(What’s this?)
    This review is from: OrbiTape Body Mass Tape Measure (Misc.)
    Very simple to use, very reliable. Nice design. Easy to read even if you have bifocals or other issues with reading it on your body.

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