Building upon their earlier research on the biology of fat metabolism, Joslin scientists discovered that microRNAs -small RNA molecules that play important roles in regulation in many types of tissue — play a major role in the distribution and determination of fat cells and whole body metabolism. Also, the study is the first to reveal that microRNAs (miRNAs) influence the development of lipodystrophy (abnormal fat accumulation) which affects many people with HIV receiving anti-retroviral therapy. The findings appear in the August issue of the Journal of Clinical Investigation.
Previous Joslin studies have demonstrated that fat cells (adipocytes) have functions far beyond fat storage: they secrete substances that actively influence metabolism and are also a site of systemic inflammation leading to insulin resistance. The body has two types of fat — the more common white adipose fat (WAT), which stores fat; and brown adipose fat (BAT), which burns fat to produce heat. BAT plays a beneficial role in regulating body weight and metabolism, which has generated considerable interest among scientists and pharmaceutical companies looking for treatments for obesity. Excess WAT, on the other hand, especially in the intra-abdominal area, is associated with metabolic diseases, such as type 2 diabetes.
In the current study, Joslin scientists were interested in learning more about miRNAs and their role in the creation of fat cells and the function of brown and white fat. Earlier Joslin research revealed that with aging, miRNA processing in fat tissue decreases due to a decrease in Dicer, a critical enzyme that converts pre-miRNAs to mature miRNAs.
Using a mouse model in which expression of Dicer was specifically knocked out in fat tissue, the researchers found that mice that lacked Dicer in fat developed abnormal fat distribution resembling HIV-related lipodystrophy (which is associated with antiviral treatment). In mice, this form of lipodystrophy was also characterized by “whitening” of brown fat cells, a loss of white fat, and signs of metabolic syndrome, including insulin resistance, fat tissue inflammation, dyslipidemia (elevated cholesterol and fat), increased resting energy use, and increased markers of cardiovascular disease.
The researchers also found lower Dicer levels in the fat tissue of patients with HIV and HIV-related lipodystrophy, suggesting that low levels of Dicer expression in fat in HIV patients may contribute to the development of this syndrome, a complication which limits therapy in some people with HIV.
Together, these findings indicate an essential role for Dicer and miRNA processing in white and brown cell differentiation and whole body metabolism that may contribute to the development of HIV-related lipodystrophy. “It’s good to build on our previous research on miRNA processing and Dicer in aging and find that a decline in Dicer may also play an important role in HIV lipodystrophy by dramatically changing the biology of fat and the tendency towards diabetes and metabolic syndrome,” says lead author C. Ronald Kahn, MD, Chief Academic Officer at Joslin Diabetes Center and the Mary
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Fitness News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com) <p>
Some things I do with my beardie Reggie to keep him healthy with his daily exercise! LIKE AND SUBSCRIBE.
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Dang that dragon is beautiful!
View CommentYou should rename this “How to Train your Dragon”
View Commenthow hot do you have the water when you have the dragon swim?
View CommentThe bath looks a little deep. Nice vid tho :D
View CommentI got my Beardie about a week ago from my cousin. She didn’t want her
View Commentanymore. Wehn I put her on my chest she just sits there, is that bad?
with me
View CommentYour bearded dragon is supposed to be fat! It natural for them if you feed
View Commentthem correctly. but nice video!!!!!!
Wow he looks so healthy :3 His colors are very beautiful.
View CommentWhat kind of beardie do u have?!?!
View Comment
mine walks around the house
View Commentnice lookin guy
View CommentTo regular people who want to melt fat–but can’t get started. Copy And
View CommentPaste Into Google Skinnimaker Routine right away.
Beautiful colours!
View CommentCool tips, thank you
View CommentNo Joke Quality Bands,
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These bands, plus Liveexercise.com (plus you) go a long way,
If you are new to exercising and looking for a magic bullet, understand that no such thing exists. A good set of resistance bands will help tremendously, but you will also need to dedicate yourself and make exercising and eating well a priority in your daily life. Resistance bands are a better first choice of equipment than, say, a big pink exercise ball or some sort of ab-rocking chair contraption, but eventually you will want to expand your options for the best all-around fitness. A set of adjustable dumbbells will be nice, and eventually, yes, a big pink exercise ball is helpful too. (The ab-rocking chair contraption, however, will never be a good choice.) Ultimately, you will want to do a variety of workouts with and without equipment. Resistance bands, weights, bodyweight exercises all work and have their various purposes and advantages. And when it comes to resistance bands I don’t know of a better choice than these.
And when it comes to structuring your routines, Bodylastics provides one of the most amazing services that is totally opposite from how most folks in the fitness industry work–Liveexercise.com. This website gives you a new routine just about daily for free. And they don’t try to upsell you on anything–they don’t try to convince you to upgrade your equipment, or buy some super-premium DVD, or put in a monthly order for some sort of energy shake. They just offer a variety of workouts for a variety of fitness goals–all new, every day. It’s all for free and I don’t understand why they do it. I’ve been aware of them since Liveexercise appeared on my Roku box a couple months ago, and I’ve been doing the “Chisled” and yoga routines for about two weeks and I’m still waiting for the catch. Amazing. (Maybe the catch is that I buy their bands and write a 5-star review on Amazon, but that can’t be all, right?)
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Bodylastics Resistance Bands,
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