2014/06/3b8d4_exercise_41uunOH45oL._SL160_

Vitamin A derivative potentially treats type 2 diabetes, prevents its cardiovascular complications

At a time when obesity, type 2 diabetes, and their complications are a veritable epidemic worldwide, researchers at the University of Montreal and CHUM Research Centre (CRCHUM) recently demonstrated the potential of retinoic acid (RA), a derivative of Vitamin A, in treating obesity and type 2 diabetes and preventing their cardiovascular complications. The findings were presented June 6, 2014 at the Annual Conference of the Canadian Nutrition Society in Saint John’s, Newfoundland.

“In obese and insulin resistant mice, retinoic acid reduces the risk of cardiac apoptosis, stimulates the expression of cardio-protective genes reduced by the disease, and protects against the accumulation of collagen in the cardiac muscle, thus avoiding the occurrence of fibrosis and possible associated future complications,” says the first author of the study, Daniel-Constantin Manolescu. Apoptosis is the process of programmed cell death. The discovery follows other research conducted by his team on the effects of RA on insulin resistance, diabetes, and obesity. “Blood glucose, insulin resistance, body weight, and adipocyte size were significantly decreased in treated animals, including abdominal fat, while dietary intake and physical activity were similar for treated or non-treated animals. This suggests an increase in basal energy expenditure,” says Manolescu. White fat is an energy reserve formed by the accumulation of fat in the form of triglycerides to meet unexpected increases in energy costs, but it is also a hormonal tissue with a delicate balance. Overall, if energy intake is greater than expenditures over an extended period, obesity increases, while hormonal balance and energy metabolism are disturbed. In this context, resistance to type 2 diabetes develops over time.

Brown fat also stores triglycerides, but it has the ability to produce heat. Abundant in babies, brown fat does not disappear completely in adulthood. It is irrigated by blood vessels and has many mitochondria, the energy factories of cells. Vitamin A derivatives stimulate a mitochondrial uncoupling protein (UCP1) that allows uncoupling of the mitochondria pathway (oxidative phosphorylation ), which uses energy from the oxidation of nutrients for the production of adenosine triphosphate (ATP). For a period of time, they generate heat (thermogenesis) instead of ATP, which is traditionally the energy required for active metabolism. Exposure to cold leads to the stimulation of brown fat and white fat, promoting the conversion of triglycerides to free fatty acids and glycerol. However, in brown adipocytes, these fatty acids are rapidly oxidized in the mitochondria and produce heat (under the influence of the UCP1 protein). Brown fat thus helps to increase basal energy metabolism. As a result, hibernating mammals fatten in the fall without developing diabetes and lose weight without moving too much in the winter (while warming their den). They are also the animals that accumulate the most Vitamin A in their livers. Retinoic acid (a Vitamin A derivative) is recognized for its involvement in cell maturation and differentiation and may guide pre-adipocytes to become brown (or beige) instead of white. It is as if “boilers” were installed directly in reserves of white fat to

… Continue reading here.
Fitness News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com) <p>

Best exercise to relief the sciatica nerve pain and cure sciatica. Visit http://www.sciaticatreatment.net for more sciatica exercises: http://www.sciaticatre…

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Comments

    • David Buiting
    • June 19, 2014
    Reply

    Science has shown that your current body have the ability to heal sciatica
    naturally, without the need for any synthetic medicines, suffer from
    hurting surgical treatment, or even changing your diet.

    View Comment
    • Edwin Thompson
    • June 19, 2014
    Reply

    Nope, not even closely feasible. The pain in my leg is quite unbearable but
    walking seems to help. It hurts and is awkward at first but the longer the
    walk and increasing my gait stride helps. After my walk the pain is almost
    non existant.

    View Comment
    • Sunya Clark
    • June 19, 2014
    Reply

    , try getting into yoga, it helps a whole lot!!

    View Comment
    • greg inniss
    • June 19, 2014
    Reply

    Oh my lord,my pain is intense,I’m trying these poses,thank you for sharing,
    my pain is down the left leg and it’s very uncomfortable ,I can’t go on
    much longer like this,Tylenol and robax help a bit but I want this to go
    now, to all you. Suffering from this, you have my. Compassion and wish your
    pain will pass soon, thanks …

    

    View Comment
    • Oliver White
    • June 19, 2014
    Reply

    @Diegon *Who Else Wants To Learn How To Relieve Their Pain And Discomfort
    From Sciatica in 7 Days (Or Less) – Guaranteed?*

    View Comment
    • Frank Branson
    • June 19, 2014
    Reply

    +Erica Zienowicz After only 32 minutes, I feel great relief from the
    *Sciatica* I have endured for the last 6 months. I expect a full recovery
    and look forward to resuming my active lifestyle.

    View Comment
    • Dina Stogsdill
    • June 19, 2014
    Reply

    sorry to say but this exercises not great for the people who exsperienced
    pain in LB or Buttock or leg ( sciatica) I just agree with knee pulling to
    the chest! The other on the back with legs up not good to lift up both legs
    together causing pain in back more, or last bending forward even worst.
    Sorry

    View Comment
    • Georgina Diaz
    • June 19, 2014
    Reply

    *Learn How to Cure Sciatica Naturally in Less Than 7 DAYS Completely with
    Unique Sciatica Treatment. No Drugs, Surgery, Physical Therapy, Exercise,
    or Change of Diet!*

    View Comment
    • Chesco
    • June 19, 2014
    Reply

    TY for this, I got sciatica in one day, must have been the slipping of the
    nerve root, its only got worse in the last 3 months, ive never had anything
    that never healed before, im dying in pain and slowly loosing my mind
    battling the pain & stress this causes. Time to educate myself and develop
    a hardcore physical plan on exercises & stretches. Im praying to god I can
    reverse this condition! :(

    View Comment
    • Ahmed Hussein
    • June 19, 2014
    Reply

    I literally can not do that last one.. fml 

    View Comment
    • Shyamal Basu
    • June 19, 2014
    Reply

    This is the exercise that my physical therapist suggested to be done a few
    times everyday. I has helped tremendously.Between the procedures the
    therapist did and this exercise I am pain free now.

    View Comment
    • Urfan A. Dar, MD
    • June 19, 2014
    Reply

    Finding a few exercises that work for you will help you manage pain caused
    by sciatica.

    1 Minute Sciatica Exercises

    View Comment
    • Timothy Lim
    • June 19, 2014
    Reply

    Hooefully this will ease my pain and allow me to heal. I’m just only 17
    years old. Having this pain for a few months now

    View Comment
    • Courtney
    • June 19, 2014
    Reply
    1 of 1 people found the following review helpful
    3.0 out of 5 stars
    handy to have on hand, October 22, 2013
    By 

    Verified Purchase(What’s this?)
    This review is from: Isokinetics Inc. Brand Economical Needle Nose Pump for Exercise/Balance Cushions – Includes Needle Nose and Regular Nozzle (Misc.)
    This works for the occasional pump to add air but was not good for the initial pump up. its nice to have around.

    0

    Help other customers find the most helpful reviews 

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    • B "myliebe"
    • June 19, 2014
    Reply
    1 of 1 people found the following review helpful
    5.0 out of 5 stars
    Works just fine, November 27, 2011
    By 
    B “myliebe” (ARLINGTON, VA, United States) –

    Verified Purchase(What’s this?)
    This review is from: Isokinetics Inc. Brand Economical Needle Nose Pump for Exercise/Balance Cushions – Includes Needle Nose and Regular Nozzle (Misc.)
    Great price for a replacement pump. I like that it has both the needle nose and excercise ball noses. Works better than the original pump that came with my gaiam excercise ball.

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