2014/06/05ad2_exercise_41fsVieLSaL._SL160_

Molecular secret of short, intense workouts clarified

In the last few years, the benefits of short, intense workouts have been extolled by both researchers and exercise fans as something of a metabolic panacea capable of providing greater overall fitness, better blood sugar control and weight reduction — all of it in periods as short as seven minutes a few times a week.

Now, in a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) confirm that there is something molecularly unique about intense exercise: the activation of a single protein.

The study, published recently by The EMBO Journal, revealed the effects of a protein known as CRTC2.

The scientists were able to show that following high-intensity exercise, which enlists the sympathetic nervous system’s “fight or flight” response, CRTC2 integrates signals from two different pathways — the adrenaline pathway and the calcium pathway, to direct muscle adaptation and growth only in the contracting muscle.

Using mice genetically modified to conditionally express CRTC2, the scientists showed that molecular changes occurred that emulated exercised muscles in the absence of exercise.

“The sympathetic nervous system gets turned on during intense exercise, but many had believed it wasn’t specific enough to drive specific adaptations in exercised muscle,” said Michael Conkright, PhD, a TSRI assistant professor who led the study. “Our findings show that not only does it target those specific muscles, but it improves them — the long-term benefits correlate with the intensity of the workout.”

Mobilizing Resources

In the genetically altered animal models, this resulted in a muscle size increase of approximately 15 percent. Metabolic parameters, indicating the amount of fuel available to the muscles, also increased substantially — triglycerides went up 48 percent, while glycogen supplies rose by a startling 121 percent.

In an exercise stress test, the genetically altered animals improved 103 percent after the gene was activated, compared to an 8.5-percent improvement in normal animals.

“If you think of the adrenaline system as something that mobilizes resources when you encounter, say, a bear on your way to work, what we found is that the system also gets you ready for your next bear encounter,” Conkright said.

The new findings open the door to a range of potential exercise enhancements.

“Nothing can supplant exercise; however, just by activating one protein, we clearly improved performance in animal models,” said Staff Scientist Nelson E. Bruno, MD, PhD, the first author of the study and a member of the Conkright laboratory. “We are now searching for molecular therapeutics that will activate the CRTC2 protein so that even an average exercise routine could potentially be enhanced and made more beneficial.”

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Fitness News — Sciencedaily
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我们的征途是星辰大海!

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Comments

    • GrandmasterTigerfist
    • June 5, 2014
    Reply

    As long as American imperialism exist , world peace is impossible. Go China!

    Greetings from India

    View Comment
    • 行 独孤
    • June 5, 2014
    Reply

    等了好久 直接到中国男人某某某去看 加油~!!

    View Comment
    • pang leong Loh
    • June 5, 2014
    Reply

    Ya way to go China show the US bastard and Japan ghost fire power .for all
    Chinese in the world do not forget our ancestors suffer from the past how
    you end up born in other country soil .we are still Chinese,

    View Comment
    • jason Chen
    • June 5, 2014
    Reply

    威武解放軍!中國人民之堅強後盾!

    View Comment
    • yr0053tf
    • June 5, 2014
    Reply

    どの民族と戦うんだ?

    View Comment
    • duy hoang
    • June 5, 2014
    Reply

    There are other ways of winning over peoples heart instead of force ‘Said
    Confucius 

    View Comment
    • Heng Cao
    • June 5, 2014
    Reply

    天朝威武!

    View Comment
    • 天子
    • June 5, 2014
    Reply

    The greatest….

    View Comment
    • bob smith
    • June 5, 2014
    Reply

    好棒,你是怎么得到这些演练视频的?

    View Comment
    • General Meow
    • June 5, 2014
    Reply

    你发的录影可真老啊

    View Comment
    • 天王
    • June 5, 2014
    Reply

    The history, us, and japan stories are fake. Pure works of fiction. China
    is the best though

    View Comment

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