2014/05/55c31_fitness_41jy7QxRowL._SL160_

Fighting cancer with dietary changes

Calorie restriction, a kind of dieting in which food intake is decreased by a certain percentage, has been touted as way to help people live longer. New research suggests that there may be other benefits, including improving outcomes for women in breast cancer. According to a study published May 26th in Breast Cancer Research and Treatment, the triple negative subtype of breast cancer — one of the most aggressive forms — is less likely to spread, or metastasize, to new sites in the body when mice were fed a restricted diet.

“The diet turned on a epigenetic program that protected mice from metastatic disease,” says senior author Nicole Simone, M.D., an associate professor in the department of Radiation Oncology at Thomas Jefferson University. Indeed, when mouse models of triple negative cancer were fed 30 percent less than what they ate when given free access to food, the cancer cells decreased their production of microRNAs 17 and 20 (miR 17/20). Researchers have found that this group of miRs is often increased in triple negative cancers that metastasize.

Breast cancer patients are often treated with hormonal therapy to block tumor growth, and steroids to counteract the side effects of chemotherapy. However, both treatments can cause a patient to have altered metabolism which can lead to weight gain. In fact, women gain an average of 10 pounds in their first year of treatment. Recent studies have shown that too much weight makes standard treatments for breast cancer less effective, and those who gain weight during treatment have worse cancer outcomes. “That’s why it’s important to look at metabolism when treating women with cancer,” says Dr. Simone.

In earlier studies, Dr. Simone and colleagues had shown that calorie restriction boosted the tumor-killing effects of radiation therapy. This study aimed to examine which molecular pathways were involved in this cooperative effect.

The investigators noticed that microRNAs — a type of RNA that regulates other genes in the cell — specifically miR 17 and 20, decreased the most when mice were treated with both radiation and calorie restriction. This decrease in turn increased the production of proteins involved in maintaining the extracellular matrix. “Calorie restriction promotes epigenetic changes in the breast tissue that keep the extracellular matrix strong,” says Dr. Simone. “A strong matrix creates a sort of cage around the tumor, making it more difficult for cancer cells to escape and spread to new sites in the body.”

Understanding the link to miR 17 also gives researchers a molecular target for diagnosing cancers that are more likely to metastasize and, potentially, for developing a new drug to treat the cancers. In theory, a drug that decreased miR 17 could have the same effect on the extracellular matrix as calorie restriction. However, targeting a single molecular pathway, such as the miR17 is unlikely to be as effective as calorie restriction, says Dr. Simone. Triple negative breast cancers tend to be quite different genetically from patient to

… Continue reading here.
Diet And Weight Loss News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com) <p>

Song: La Vida Es Un Carnaval Joining me is my amazing friend and zumba sister Mari Wiklund..also a ZIN! -Hope you like it! Follow me on facebook: https://www…
Video Rating: 4 / 5

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Comments

    • Lourdes Castillo Castillar
    • May 27, 2014
    Reply

    Are you having whole zumba classes?? This clips are ok, but 40-50 minutes
    classes would help us much more. 

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    • achi achida
    • May 27, 2014
    Reply

    thx i like it 

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    • Betul Ozlu
    • May 27, 2014
    Reply

    Zumba?? No and yes=

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    • Maria AllwaysGrumpy
    • May 27, 2014
    Reply

    Trival) routine. Please. Great Video

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    • Stefania Vergara Vallejo
    • May 27, 2014
    Reply

    Can you post a complete zumba class please?? like the ones of 30 minutes
    you have! thanks! :)

    View Comment
    • estrellablush
    • May 27, 2014
    Reply

    Please do more 30 minutes zumba workout!! :-)

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    • donatellag635
    • May 27, 2014
    Reply

    Yeee great song great zumba!

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    • Gaurav Bhattarai
    • May 27, 2014
    Reply

    My coworkers laughed when I told them I would melt fat with Fat Blast
    Furnace, but then they saw the results. Go google Fat Blast Furnace to see
    their reaction. (You should see their shock!)

    View Comment
    • autoneto
    • May 27, 2014
    Reply

    slow down a bit and it will be match the melody. 

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    • Monika Bagińska
    • May 27, 2014
    Reply

    You are amazing . Exercises with you three weeks. I see the effect.
    THANKS!!!!!!!.
    Greetings from POLISH.!!! :)

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    • YOS LIHGTNING
    • May 27, 2014
    Reply

    nice!!!

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    • YOS LIHGTNING
    • May 27, 2014
    Reply

    linda pretty girl

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    • April "April"
    • May 27, 2014
    Reply
    10 of 10 people found the following review helpful
    3.0 out of 5 stars
    loses air easily, December 17, 2012
    By 
    April “April” (New York) –

    Verified Purchase(What’s this?)
    This review is from: Sunny Health & Fitness Anti-Burst Gym Ball (Sports)
    I am pregnant and bought this ball to help my babe engage. It’s GREAT when you pack it full, but then a day or two later you’ll notice it has lost a significant amount of air. I know these balls are meant to be “refueled” but every 2 days is very often!

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    • K. Findley
    • May 27, 2014
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    12 of 13 people found the following review helpful
    5.0 out of 5 stars
    The BEST, November 30, 2012
    By 
    K. Findley (Orange County, Ca.) –
    (REAL NAME)
      

    Verified Purchase(What’s this?)
    Very strong and sturdy. I am a, ahem, big girl, and it works great for me. I just love it.

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