2014/04/5b1eb_exercise_41EEnp0kTmL._SL160_

Novel approach to accelerate metabolism could lead to new obesity treatment

By manipulating a biochemical process that underlies cells’ energy-burning abilities, investigators at Beth Israel Deaconess Medical Center (BIDMC) have made a novel discovery that could lead to a new therapy to combat obesity and diabetes.

Published in the April 10 issue of the journal Nature, the new findings show that reducing the amount of nicotinamide N-methyltransferase (NNMT) protein in fat and liver dramatically reduces the development of obesity and diabetes in mice.

‘With this discovery, we now have a means of metabolic manipulation that could help speed energy production and lead to weight loss,” explains senior author Barbara Kahn, MD, Vice Chair of the Department of Medicine at BIDMC and George Richards Minot Professor of Medicine at Harvard Medical School. “Our findings are particularly exciting because the antisense oligonucleotide [ASO] technology we used to inhibit the NNMT gene in our study is already being used to treat other diseases in humans.”

NNMT is an enzyme that processes vitamin B3 and has been linked to certain types of cancer, as well as Alzheimer’s disease, explains co-corresponding author Qin Yang, MD, PhD, a Klarman Scholar in the Kahn laboratory at BIDMC and Assistant Professor of Medicine at Harvard Medical School. “Now we have identified an entirely new role for this enzyme in fat tissue, and that is to regulate energy metabolism,” he adds.

The new findings hinge on a biochemical mechanism known as a futile cycle, in which cellular reactions are sped up, thereby generating more energy. “We all know people who can seemingly eat whatever they want and not gain weight,” explains Kahn. “Part of the reason for this natural weight control owes to basal cellular metabolism – the body’s inherent rate of burning energy. A futile cycle is one way to speed up energy utilization in cells.”

The investigators first confirmed that levels of NNMT were increased in obese and diabetic mice.

“In a comparison of genetic profiles of fat from mice that were either prone to or protected from developing diabetes, we discovered that the animals that were prone to develop diabetes had a lot of NNMT in the fat and liver,” explains Yang. Together with co-first author Daniel Kraus, MD, Kahn and Yang hypothesized that reducing NNMT levels in these tissues would accelerate a series of metabolic reactions involving molecules called polyamines, thereby leading to increased energy expenditure, increased leanness and reduced risk of diabetes and its complications.

“Polyamines are a group of biological molecules that are found throughout the body, which have fundamental functions, including regulating cell growth,” explains Kraus. “What’s interesting about the polyamines is that the process of building and degrading them creates a biochemical cycle in which energy is used up. This is a futile cycle.” The team discovered that NNMT inhibition speeds up this futile cycle, resulting in more dietary calories being burned for energy and fewer calories being incorporated

… Continue reading here.
Fitness News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com) <p>

On this episode of Miss Hannah Minx’s JWOW (Japanese Word Of the Week) our word is undousuru. Undousuru means ‘to exercise.’ Miss Hannah Minx likes to do pus…

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Comments

    • zakmeninferno
    • April 11, 2014
    Reply

    It is like a porn

    View Comment
    • KatyBandida
    • April 11, 2014
    Reply

    beautiful hair .

    View Comment
    • elmetgwennhudkoad
    • April 11, 2014
    Reply

    Hey miss Hannah Minx, you have an amazing body and I’m sure you know it,
    but I’m also sure you have much more to offer to the world than just
    beauty, I don’t watch your videos only because of your physical beauty,
    Mate ne

    View Comment
    • Bobb Graziano
    • April 11, 2014
    Reply

    Hey Beautiful Girl,

    You know,You were only being a exhibitionist and showing off, how BIG &
    BEAUTIFUL,Your Breasts are! Admit it!!!

    View Comment
    • Sunny C
    • April 11, 2014
    Reply

    Boobies.

    View Comment
    • DO7MOS
    • April 11, 2014
    Reply

    My undosoru is to fap to ur boobs :O

    View Comment
    • KomaStylez | EDiT's :D
    • April 11, 2014
    Reply

    Im probs the only one that watches this because i want to learn japanese
    @_@

    View Comment
    • Arda Arslan
    • April 11, 2014
    Reply

    ( o )( o )

    View Comment
    • HSGingerBiscuit
    • April 11, 2014
    Reply

    0:45 I think you out the annotation in the wrong place XD

    View Comment
    • Andrew Hill
    • April 11, 2014
    Reply

    Damn I remember when this video went like viral lmao

    View Comment
    • D3ATHGOOSE
    • April 11, 2014
    Reply

    whoa… talking bewbs!

    View Comment
    • Gree Sent o
    • April 11, 2014
    Reply

    I wonder if anyone responded to this with a video of them masturbating.

    View Comment
    • Matt Raines
    • April 11, 2014
    Reply

    yesss… check out the “weights”…

    View Comment
    • thejonesmail
    • April 11, 2014
    Reply

    becouse of the boobs she has :3

    View Comment
    • Mastermillerwarrier
    • April 11, 2014
    Reply

    I can tell people are only hear for her tits

    View Comment
    • Robert B. Althouse
    • April 11, 2014
    Reply
    152 of 155 people found the following review helpful
    5.0 out of 5 stars
    100% Integrity, January 19, 2007
    By 
    Robert B. Althouse (Chicago) –
    (REAL NAME)
      

    This review is from: Max Fitness 75cm Exercise Ball with Foot Pump (Black) (Sports)
    I had a shipping problem with my ball, and I also ended up with the wrong size. Max Fitness went the extra mile and met all of my needs with 100% integrity. They were pro-active and gracious.

    I also love the ball. One qualification for those of you considering getting a ball. The size of the ball may depend on not only your height but what you are using it for. In my case, I’m 6′ tall and I use the ball to do Core Exercises as taught by Gunnar Peterson and the 65 cm ball is definately too small for me. The 75 cm ball works for me, and I’m completely satisfied both with it’s quality and the excellent service I received from Max Fitness in the process.

    You can’t go wrong with these folks.

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    • yourlibrarian
    • April 11, 2014
    Reply
    130 of 134 people found the following review helpful
    5.0 out of 5 stars
    Good price for a sturdy product, August 12, 2006
    By 
    yourlibrarian (USA) –

    Amazon Verified Purchase(What’s this?)
    This review is from: Max Fitness 75cm Exercise Ball with Foot Pump (Black) (Sports)
    I bought this item to use as a chair replacement, which means it likely gets used more often than if for exercise. I bought this items a month ago and have used it almost daily since. To date I have not had to reinflate the ball and it has been sturdy and comfortable. The enclosed pump didn’t inspire a lot of confidence but actually worked just fine, and given the fact that it may not require a lot of use, should be suitable for the life of the ball.

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