Dec. 19, 2012 Obese, postmenopausal women are at greater risk for developing breast cancer and their cancers tend to be more aggressive than those in lean counterparts. A University of Colorado Cancer Center study published in the December issue of the journal Cancer Research shows how this risk might be prevented.
“By using nutrient tracers for fat and sugar, we tracked where the body stored excess calories. In lean models, excess fat and glucose were taken up by the liver, mammary and skeletal tissues. In obese models, excess fat and glucose were taken up by tumors, fueling their growth,” says Erin Giles, PhD, postdoctoral researcher at the CU Cancer Center and the paper’s lead author.
In short, if you are lean, excess calories go to healthy tissue. If you are obese, excess calories feed the tumor.
“This implies that the menopausal window may be an opportunity for women to control their breast cancer risk through weight management,” Giles says.
In this study, Giles worked with a team of scientists including postdoctoral fellows Elizabeth Wellberg and Sonali Jindal, as well as faculty members Steve Anderson, Pepper Schedin, Ann Thor and Paul Maclean. Their study also showed that tumors from obese animals had increased levels of the progesterone receptor, and this receptor appears to give tumors a metabolic advantage for growth. To extend their findings to humans, they recruited gene analysis experts David Astling and Aik-Choon Tan who analyzed 585 human breast cancers and found that human tumors expressing the progesterone receptor had the same metabolic advantage.
“Basically, we saw an abnormal metabolic response to fat and sugar in the obese that, in many ways, mirrors the response to fat and sugar in Type II diabetes,” Giles says. Noticing this similarity, the group tested the use of the common Type II diabetes drug, Metformin, in their model of postmenopausal breast cancer.
“With treatment, tumor size was dramatically decreased in the obese, and tumors showed reduced expression of the progesterone receptor,” Giles says.
Using a pre-clinical model, the investigators found that weight gain during menopause is particularly bad for those who are obese when entering menopause. Together, the results of this study suggest that the combination of obesity and weight gain during menopause can impact breast cancer in two ways. First, tumors that arise in obese women appear to have a metabolic advantage, and second, the inability to store excess calories in healthy tissues may further fuel tumor growth.
“While drugs may be useful in controlling breast cancer risk in obese, postmenopausal women, our results imply that a combination of diet and exercise may be equally if not more beneficial,” Giles says.
The group’s ongoing studies are testing whether interventions such as diet and exercise, during the period of menopausal weight gain, can improve tumor outcomes.
Share this story on Facebook, Twitter, and Google:
Other social bookmarking and sharing tools:
The above story is reprinted from materials provided by University of Colorado Denver. The original article was written by Garth Sundem.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
- E. D. Giles, E. A. Wellberg, D. P. Astling, S. M. Anderson, A. D. Thor, S. Jindal, A.-C. Tan, P. S. Schedin, P. S. MacLean. Obesity and Overfeeding Affecting Both Tumor and Systemic Metabolism Activates the Progesterone Receptor to Contribute to Postmenopausal Breast Cancer. Cancer Research, 2012; 72 (24): 6490 DOI: 10.1158/0008-5472.CAN-12-1653
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
- ^ materials (www.coloradocancerblogs.org)
- ^ University of Colorado Denver (www.ucdenver.edu)
- ^ 10.1158/0008-5472.CAN-12-1653 (dx.doi.org)
Be Well On Your Way: Journey to a More Authentic You (Paperback) tagged “healthy lifestyle” 88 times
Wed, 10 Nov 2010 00:25:58 GMT Be Well On Your Way: Journey to a More Authentic You (Paperback)By Maiysha T Clairborne MD Click for more info Customer Rating: Customer tags: mind body spirit(90), self-help(90), empowerment(89), personal growth(88), healthy lifestyle(88), health(88), healthy living(85), healthy life(85), personal development(81), relationships(79), self esteem(35), self-improvement(35) http://www.amazon.com/Be-Well-Your-Way-Authentic/dp/1453614095/ref=tag_rso_rs_edpp_url?ie=UTF8&creative=381421&tag=thedays-20
Life On Your Terms: 7 Steps To a More Empowered You (Paperback) tagged “healthy lifestyle” 88 times
Wed, 26 Jan 2011 03:27:19 GMT Life On Your Terms: 7 Steps To a More Empowered You (Paperback)By Maiysha T Clairborne MD Click for more info Customer Rating: Customer tags: self-help(91), empowerment(89), health(89), healthy living(88), healthy lifestyle(88), healthy life(87), personal development(86), mind body spirit(86), personal growth(84), relationships(81), self-improvement(41), self esteem(40) http://www.amazon.com/Life-On-Your-Terms-Empowered/dp/1453615040/ref=tag_rso_rs_edpp_url?ie=UTF8&creative=381421&tag=thedays-20
Programs promote healthy lifestyles | Windsor Star
There is a growing concern that today's young people do not lead a healthy enough lifestyle. They are generally not as active as they should be and do not eat well. An active lifestyle is important for all people but especially for … http://blogs.windsorstar.com/2012/12/17/programs-promote-healthy-lifestyles/
A healthy lifestyle is important | YWAM Heidebeek
For those who want to gain knowledge about healthy food and who want to apply it practically, you are welcome to attend the Real Food Seminar. Food expert Craig Chanda will teach the seminar on Friday and Saturday, January 4 and 5 at … http://ywamheidebeek.org/%E2%80%9Ca-healthy-lifestyle-is-important%E2%80%9D/
WEIGHT WATCHERS HEALTHY LIFE STYLE COOKBOOK
Tony Little Cheeks Healthy Lifestyle Thong Flip Flop Sandals White Size 8
Click here for reuse options!
Copyright 2012 HealthNutFitness
Click here for more information about 'Healthy Lifestyle During Menopause May Decrease Breast Cancer Risk Later On'.