2014/03/e6a78_fitness_41QhibJ438L._SL160_

Gut metabolism changes — not stomach size — linked to success of vertical sleeve gastrectomy

It’s not the size of the stomach that causes weight loss after a specific type of bariatric surgery, but rather a change in the gut metabolism, say researchers from the University of Cincinnati (UC), the University of Gothenburg in Sweden and Cincinnati Children’s Hospital Medical Center.

The scientists, publishing their results in the March 26, 2014, advanced online edition of Nature, have found that following vertical sleeve gastrectomy, there is a change in bile acids that bind to a nuclear receptor called FXR. In the absence of FXR, the researchers showed, weight-loss success and improvement in diabetes from vertical sleeve gastrectomy is reduced.

Vertical sleeve gastrectomy, VSG, is a bariatric procedure in which approximately 80 percent of the stomach is removed to create a gastric “sleeve,” which imposes a physical restriction on the amount of food that can be consumed at one time.

“There are very large debates over how small to make the sleeve,” says co-principal investigator Randy Seeley, PhD, professor in the endocrinology, diabetes and metabolism division at UC and director of the Cincinnati Diabetes and Obesity Center. “Conventional thought is when you make the stomach smaller, patients lose more weight because they have less room to put more food and, therefore, eat fewer calories. But as it turns out, the reason why the surgery works is that you are changing the bile acids.”

This study, Seeley says, is the first empirical evidence that the therapeutic value of VSG is not a result of the mechanical restriction of a smaller stomach, but the result of increased circulating bile acids that are known to bind to the nuclear receptor FXR.

That discovery, he says, was made in a mouse model by removing the FXR receptor in obese mice that had undergone VSG. Despite having a smaller pouch, or “sleeve,” Seeley says, rodents without the FXR receptor didn’t lose weight.

Because bile acids and FXR receptors interact with gut microbial communities, the researchers also looked at gut bacteria after VSG. They found that the surgery also results in changes in the gut bacteria.

“Importantly, we observed changes in several key bacterial groups that have been previously linked to the risk of Type 2 diabetes, and these changes were related to FXR and bile acids,” says Karen Ryan, PhD, lead author and assistant professor of endocrinology, diabetes and metabolism at UC.

“Manipulating the gut bacteria is another way we think that we might be able to mimic how surgery works without having to do the cutting and stapling,” Seeley says.

The significance of this study is in the exploration of future treatments for obesity and Type 2 diabetes, as bariatric surgery is proven to provide substantial improvements in obesity and obesity-related conditions.

“There are not enough surgery tables or surgeons to treat the obesity epidemic, so we need to understand how bariatric surgery works so that we can

… Continue reading here.
Diet And Weight Loss News — Sciencedaily
— Courtesy “Science News Daily” (ScienceNewsDaily.com) <p>

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Comments

    • Rose Kimberly
    • March 26, 2014
    Reply

    Thank you guys so much for all the love and watching my new video! I’m so
    happy this video is helpful to you. I always try to give great content to
    you every week. So happy you enjoyed! So so happy haha. Love you and hope
    you had a great Monday! Enjoy the rest of your week. See ya on Thursday!

    View Comment
    • Rose Kimberly
    • March 26, 2014
    Reply

    NEW VIDEO Love;) I show you how i workout to stay healthy. If you learned
    something new Please LIKE,COMMENT & SUBSCRIBE. I love chatting so leave me
    a comment and let me know what video you want to see next. Hope you had a
    good weekend and Happy Sunday!

    View Comment
    • yourfavoritenisha
    • March 27, 2014
    Reply

    loved it! what a hottie! ur so fit!! I’m going to use some of these
    workouts

    View Comment
    • BeautifulHearts101
    • March 27, 2014
    Reply

    soooo helpful! thanks girll!!!

    View Comment
    • Marina Martin
    • March 27, 2014
    Reply

    Omg! Baby got back haha you are my absolute favorite beauty guru :D

    View Comment
    • Ciarahoneydip
    • March 27, 2014
    Reply

    Omg I love the intro! You look great boo!:)

    View Comment
    • Tracy Timberlake
    • March 27, 2014
    Reply

    Love this! You have so much energy!!! Girl you made me wanna throw my
    sneakers on and join you! I’m definitely gonna try some of these especially
    the seated cheerleader kick one!!!! Thanks for the tips girl! So excited to
    see the next one! 

    View Comment
    • Armani Styles
    • March 27, 2014
    Reply

    Great video love! x

    View Comment
    • MISSYANYI♡BeautynLife
    • March 27, 2014
    Reply

    girllll!! get it!!! 

    View Comment
    • saka2ya
    • March 27, 2014
    Reply

    Thanks for the tips, I’ll try them out later today!

    View Comment
    • Shayna Bacon
    • March 27, 2014
    Reply

    Fun! I was a varsity cheerleader:)

    View Comment
    • Sami Amelia Chisala
    • March 27, 2014
    Reply

    Girl they hurt lol Great work out thou followed it step by step ur awesome
    Love you 

    View Comment
    • CvG1111
    • March 27, 2014
    Reply

    Yess! I needed this 😀 definitely gonna try it out 

    View Comment
    • asimone
    • March 27, 2014
    Reply

    I was a cheerleader too in HS and I was in the best shape but since I’ve
    been in college I’ve gained like 20 pounds and it all goes to my thighs and
    butt :O Thanks Rose for these work outs I will give them a try :)

    View Comment
    • Jacob Gutierrez
    • March 27, 2014
    Reply

    LOVE IT!! LOVE IT!! would love for you to check out my BEAUTY VIDEOS on my
    Channel!! 🙂 XoXo

    View Comment
    • GLambySaur
    • March 27, 2014
    Reply

    Yay! I’m so glad you did this video because I wanted to request you to do
    workout routine video and the next day it’s here, haha! 🙂 can’t wait for
    the next part! As for me, I love blogilates, she has awesome workouts and I
    just prefer to work out ‘with somebody’ than on my own because I would
    probably not force myself to do anything :D

    View Comment
    • itshaloo
    • March 27, 2014
    Reply

    you are in suuuuch a good shape rose!! boyinspiration right here girl <3 

    View Comment
    • BeautieSquared
    • March 27, 2014
    Reply

    you have an amazing body!! I don’t know what it is, but your personality
    reminds me of the disney character ‘that’s so raven’ hence why i love your
    videos so much! she was my favorite!!! loved this video rose 🙂 – Maria
    xxoxx

    View Comment
    • Christina Cange
    • March 27, 2014
    Reply

    Great video girl! I really need to start a routine for myself. The
    exercises you showed will definitely help. Thanks! 

    View Comment
    • cupcake11092
    • March 27, 2014
    Reply

    Where did you get those shorts?!?!

    View Comment
    • theessenceofbeauty1g
    • March 27, 2014
    Reply

    Whats the name of the song at the start? Great video, just what I needed ♡

    View Comment
    • Kym .B
    • March 27, 2014
    Reply

    Good work out tips

    View Comment
    • MG
    • March 27, 2014
    Reply
    24 of 25 people found the following review helpful
    5.0 out of 5 stars
    Perfect size for my height, December 22, 2012
    By 
    MG

    Amazon Verified Purchase(What’s this?)
    This review is from: Tone Fitness Stability Ball (Sports)
    I wanted to get a stability ball to work on at home. I was not able to figure out which size ball I should take for my height. I looked around and people said different things. I decided to buy this 65 cm ball and it was perfect for my height. It looked big after I inflate it, but when I worked out on it, it was perfect for my height. I am 5’10” btw.

    I have seen people complaining about the pump. I don’t know what they are expecting. You would, of course, not get a $10 pump with a $16 stability ball. The pump which comes with this ball worked fine, at least for me. Yes, it is small pump and it is a workout in itself to inflate the ball with a this pump (because it’s a small pump and you have pump a lot), but I did inflate the ball. The pump didn’t break or anything. And you don’t inflate-deflate a stability ball on daily basis, until and unless that is what you do for a time pass.

    I would recommend this product for someone who is 5’8″-6″ tall.

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    • Heather
    • March 27, 2014
    Reply
    10 of 11 people found the following review helpful
    5.0 out of 5 stars
    Awesome birthing ball!, June 17, 2013
    By 
    Heather

    Amazon Verified Purchase(What’s this?)
    This review is from: Tone Fitness Stability Ball (Sports)
    I will say I used this ball as a birthing ball. I know it was not originally designed for that but it works very for the birthing process to take some of the pressure off of your pelvic area. I am 5ft 2in and this ball was a good height for me! If you are thinking about a natural birth, and wanting a good tool to relieve your pain than try this! It is a must have!

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